2026-09-24T15:08:20Z https://epublications.vu.lt/oai

oai:vu.lt:elaba:210578007 2026-07-04T21:23:37Z openaireNDLTDDRIVER

Bioaktyviųjų joninių skysčių aukštosios skyros BMR tyrimas /High resolution nmr study of bioactive ionic liquids.Mikalauskas, Lukas,info:eu-repo/semantics/openAccessBioactive room temperature ionic liquids (b-RTIL) are getting more popular in the field of ionic liquids. The ionic liquids are composed of organic cation molecules and organic or inorganic molecule anions. IL have low melting temperature; low vapour pressure and their chemical structure can be altered. b-RTILs are different from the regular IL since b-RTILs are compatible with the human organism. That means, that b-RTIL can be used in medicine by increasing drug solubility in water. NMR spectroscopy is used to analyse b-RTILs – choline lysinate, choline tryptophanate and choline glycinate ([Ch][Lys], [Ch][Trp] and [Ch][Gly]). Also, with NMR we can analyse [Ch][Lys] interaction with water molecules by measuring the chemical shift of both water molecule and [Ch][Lys] protons at the b-RTIL concentration between 10-5 and 1 molar fraction. [Ch][Lys] cation protons’ chemical shifts reach the plateau at χ_RTIL=10^(-4). molar fraction. The chemical shifts of [Lys] anion protons do not reach the plateau at the measured concentration interval. Water molecule chemical shift plateaus at χ_RTIL=1,5×10^(-2) molar fraction. In [Ch][Trp] water mixture, all molecules chemical shift plateaus at χ_RTIL=10^(-4) molar fraction. In [Ch][Gly] cation protons chemical shift stabilizes at a concentration of χ_RTIL=〖4×10〗^(-4) molar fraction while anion proton chemical shift stabilizes at 〖2,5×10〗^(-5) molar fraction. Water chemical shift plateaus at a concentration of 2×10^(-5) molar fraction.Institutional Repository of Vilnius Universityinfo:eu-repo/semantics/bachelorThesislit2024application/pdfhttps://epublications.vu.lt/object/elaba:210578007/210578007.pdfhttps://repository.vu.lt/VU:ELABAETD210578007&prefLang=en_US