Title CKM gene rs8111989 polymorphism and power athlete status /
Authors Ginevičienė, Valentina ; Jakaitienė, Audronė ; Utkus, Algirdas ; Hall, Elliott C. R ; Semenova, Ekaterina A ; Andryushchenko, Liliya B ; Larin, Andrey K ; Moreland, Ethan ; Generozov, Edward V ; Ahmetov, Ildus I
DOI 10.3390/genes12101499
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Is Part of Genes.. Basel : MDPI. 2021, vol. 12, iss. 10, art. no. 1499, p. [1-8].. eISSN 2073-4425
Keywords [eng] anaerobic performance ; creatine kinase ; genetic variant ; genotype
Abstract [eng] Multiple genetic variants are known to influence athletic performance. These include polymorphisms of the muscle-specific creatine kinase (CKM) gene, which have been associated with endurance and/or power phenotypes. However, independent replication is required to support those findings. The aim of the present study was to determine whether the CKM (rs8111989, c.*800A>G) polymorphism is associated with power athlete status in professional Russian and Lithuanian competitors. Genomic DNA was collected from 693 national and international standard athletes from Russia (n = 458) and Lithuania (n = 235), and 500 healthy non-athlete subjects from Russia (n = 291) and Lithuania (n = 209). Genotyping for the CKM rs8111989 (A/G) polymorphism was performed using PCR or micro-array analysis. Genotype and allele frequencies were compared between all athletes and non-athletes, and between non-athletes and athletes, segregated according to population and sporting discipline (from anaerobic-type events). No statistically significant differences in genotype or allele frequencies were observed between non-athletes and power athletes (strength-, sprint- and speed/strength-oriented) athletes. The present study reports the non-association of the CKM rs8111989 with elite status in athletes from sports in which anaerobic energy pathways determine success.
Published Basel : MDPI
Type Journal article
Language English
Publication date 2021
CC license CC license description