Title Risk factors for complicated community-acquired pneumonia course in patients treated with β-lactam monotherapy /
Authors Cincilevičiūtė, Giedrė ; Averjanovaitė, Vaida ; Mereškevičienė, Rūta ; Pliatkienė, Gabrielė ; Zablockis, Rolandas ; Danila, Edvardas
DOI 10.5603/ARM.a2021.0070
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Is Part of Advances in respiratory medicine.. Gdańsk : Via Medica. 2021, vol. 89, iss. 4, p. 359-368.. ISSN 2451-4934. eISSN 2543-6031
Keywords [eng] community-acquired pneumonia ; complications. ; mortality ; β-lactam monotherapy
Abstract [eng] INTRODUCTION: We aimed to investigate community-acquired pneumonia (CAP) requiring hospitalisation, empirically treated with b-lactam monotherapy, with 30-day mortality and risk factors predicting its complicated course. MATERIAL AND METHODS: A prospective observational study was conducted at the Pulmonology and Allergology Department in a tertiary care university hospital. 253 consecutive patients diagnosed with CAP requiring hospitalisation were enrolled. Hospital admission was based on PSI or CRB-65 scores, severe comorbidities, signs of intoxication, aspiration risk, social risk consider-ations, ineffective prior antibiotic treatment. RESULTS: Fourty seven percent of the subjects had complications on admission, 13% developed new CAP complications during inpatient treatment. Overall, 53% of individuals had a complicated CAP course. 30-day mortality rate was 5.9%. The factors predicting a complicated CAP course were as follows: neuromuscular disease, multilobar opacities on chest X-ray (or computed tomography), and clinically unstable condition as evaluated using Halm's criteria. CONCLUSIONS: The mortality rate in CAP patients treated with b-lactam monotherapy is low. Neuromuscular disease, multilobar opacities, and clinically unstable condition as evaluated using Halm's criteria predict a complicated CAP course.
Published Gdańsk : Via Medica
Type Journal article
Language English
Publication date 2021
CC license CC license description