In-season and out-of-season variation of rotavirus genotype distribution and age of infection across 12 European countries before the introduction of routine vaccination, 2007/08 to 2012/13 /

D Hungerford; R Vivancos; J. M Read; V. E Pitzer; N Cunliffe; N French; M Iturrizagómara; Stephan Aberle; Marc Van Ranst; Jelle Matthijnssens; Mark Zeller; Zornitsa Mladenova; Sofie Midgley; Thea Kølsen Fischer; Vassiliki P Syriopoulou; Dimitra M Koukou; Krisztián Bányai; Renáta Dóró; Jérôme Kaplon; Pierre Pothier; Leena Maunula; Franco Maria Ruggeri; Lucia Fiore; Vytautas Usonis; Inga Ivaškevičienė; Harry Vennema; Annelies Kroneman; Mateja Poljsak-Prijatelj; Andrej Steyer; Javier Buesa; Gustavo Cilla; Milagroasa Montes; Mia Brytting; Lottie Schloss; Andreas Mas Marques; David James Allen; Sameena Nawaz

doi:10.2807/1560-7917.ES.2016.21.2.30106

Title	In-season and out-of-season variation of rotavirus genotype distribution and age of infection across 12 European countries before the introduction of routine vaccination, 2007/08 to 2012/13 /
Authors	Hungerford, D ; Vivancos, R ; Read, J. M ; Pitzer, V. E ; Cunliffe, N ; French, N ; Iturrizagómara, M ; Aberle, Stephan ; Van Ranst, Marc ; Matthijnssens, Jelle ; Zeller, Mark ; Mladenova, Zornitsa ; Midgley, Sofie ; Fischer, Thea Kølsen ; Syriopoulou, Vassiliki P ; Koukou, Dimitra M ; Bányai, Krisztián ; Dóró, Renáta ; Kaplon, Jérôme ; Pothier, Pierre ; Maunula, Leena ; Ruggeri, Franco Maria ; Fiore, Lucia ; Usonis, Vytautas ; Ivaškevičienė, Inga ; Vennema, Harry ; Kroneman, Annelies ; Poljsak-Prijatelj, Mateja ; Steyer, Andrej ; Buesa, Javier ; Cilla, Gustavo ; Montes, Milagroasa ; Brytting, Mia ; Schloss, Lottie ; Marques, Andreas Mas ; Allen, David James ; Nawaz, Sameena
DOI	10.2807/1560-7917.ES.2016.21.2.30106
Full Text
Is Part of	Eurosurveillance.. Stockholm : European Centre for Disease Prevention and Control (ECDC). 2016, vol. 21, iss. 2, p. 136-141.. ISSN 1025-496X. eISSN 1560-7917
Abstract [eng]	The EuroRotaNet surveillance network has conducted rotavirus genotype surveillance since 2007 in 16 European countries. Using epidemiological and microbiological data from 39,786 genotyped rotavirus-positive specimens collected between September 2007 and August 2013, we assessed genotype distribution and age distribution of rotavirus gastroenteritis (RVGE) cases in and out of peak season in 12 countries which were yet to implement routine rotavirus vaccination. In multinomial multivariate logistic regression, adjusting for year, country and age, the odds of infection caused by genotype-constellation 2 DS-1-like stains (adjusted multinomial odds ratio (aM-OR) = 1.25; 95% confidence interval (CI): 1.13–1.37; p < 0.001), mixed or untypable genotypes (aM-OR = 1.55; 95% CI: 1.40–1.72; p < 0.001) and less common genotypes (aM-OR = 2.11; 95% CI:1.78–2.51; p < 0.001) increased out of season relative to G1P[8]. Age varied significantly between seasons; the proportion of RVGE cases younger than 12 months in the United Kingdom increased from 34% in season to 39% out of season (aM-OR = 1.66; 95% CI: 1.20–2.30), and the proportion five years and older increased from 9% in season to 17% out of season (aM-OR = 2.53; 95% CI: 1.67–3.82). This study provides further understanding of the rotavirus ecology before vaccine introduction, which will help interpret epidemiological changes in countries introducing or expanding rotavirus vaccination programmes.
Published	Stockholm : European Centre for Disease Prevention and Control (ECDC)
Type	Journal article
Language	English
Publication date	2016
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„In-season and out-of-season variation of rotavirus genotype distribution and age of infection across 12 European countries before the introduction of routine vaccination, 2007/08 to 2012/13 /“