Emergence and spread of SARS-CoV-2 lineage B.1.620 with variant of concern-like mutations and deletions /

Gytis Dudas; Samuel L Hong; Barney I Potter; Sébastien Calvignac-Spencer; Frédéric S Niatou-Singa; Thais B Tombolomako; Terence Fuh-Neba; Ulrich Vickos; Markus Ulrich; Fabian H Leendertz; Kamran Khan; Carmen Huber; Alexander Watts; Ingrida Olendraitė; Joost Snijder; Kim N Wijnant; Alexandre M J J Bonvin; Pascale Martres; Sylvie Behillil; Ahidjo Ayouba; Martin Foudi Maidadi; Dowbiss Meta Djomsi; Celestin Godwe; Christelle Butel; Aistis Šimaitis; Miglė Gabrielaitė; Monika Katėnaitė; Rimvydas Norvilas; Ligita Raugaitė; Giscard Wilfried Koyaweda; Jephté Kaleb Kandou; Rimvydas Jonikas; Inga Nasvytienė; Živilė Žemeckienė; Dovydas Gečys; Kamilė Tamušauskaitė; Milda Norkienė; Emilija Vasiliūnaitė; Danguolė Žiogienė; Albertas Timinskas; Marius Šukys; Mantas Šarauskas; Gediminas Alzbutas; Adrienne Amuri Aziza; Eddy Kinganda Lusamaki; Jean-Claude Makangara Cigolo; Francisca Muyembe Mawete; Emmanuel Lokilo Lofiko; Placide Mbala Kingebeni; Jean-Jacques Muyembe Tamfum; Marie Roseline Darnycka Belizaire; René Ghislain Essomba; Marie Claire Okomo Assoumou; Akenji Blaise Mboringong; Alle Baba Dieng; Dovilė Juozapaitė; Salome Hosch; Justino Obama; Mitoha Ondo'o Ayekaba; Daniel Naumovas; Arnoldas Pautienius; Clotaire Donatien Rafaï; Astra Vitkauskienė; Rasa Ugenskienė; Alma Gedvilaitė; Darius Čereškevičius; Vaiva Lesauskaitė; Lukas Žemaitis; Laimonas Griškevičius; Guy Baele

doi:10.1038/s41467-021-26055-8

Title	Emergence and spread of SARS-CoV-2 lineage B.1.620 with variant of concern-like mutations and deletions /
Authors	Dudas, Gytis ; Hong, Samuel L ; Potter, Barney I ; Calvignac-Spencer, Sébastien ; Niatou-Singa, Frédéric S ; Tombolomako, Thais B ; Fuh-Neba, Terence ; Vickos, Ulrich ; Ulrich, Markus ; Leendertz, Fabian H ; Khan, Kamran ; Huber, Carmen ; Watts, Alexander ; Olendraitė, Ingrida ; Snijder, Joost ; Wijnant, Kim N ; Bonvin, Alexandre M J J ; Martres, Pascale ; Behillil, Sylvie ; Ayouba, Ahidjo ; Maidadi, Martin Foudi ; Djomsi, Dowbiss Meta ; Godwe, Celestin ; Butel, Christelle ; Šimaitis, Aistis ; Gabrielaitė, Miglė ; Katėnaitė, Monika ; Norvilas, Rimvydas ; Raugaitė, Ligita ; Koyaweda, Giscard Wilfried ; Kandou, Jephté Kaleb ; Jonikas, Rimvydas ; Nasvytienė, Inga ; Žemeckienė, Živilė ; Gečys, Dovydas ; Tamušauskaitė, Kamilė ; Norkienė, Milda ; Vasiliūnaitė, Emilija ; Žiogienė, Danguolė ; Timinskas, Albertas ; Šukys, Marius ; Šarauskas, Mantas ; Alzbutas, Gediminas ; Aziza, Adrienne Amuri ; Lusamaki, Eddy Kinganda ; Cigolo, Jean-Claude Makangara ; Mawete, Francisca Muyembe ; Lofiko, Emmanuel Lokilo ; Kingebeni, Placide Mbala ; Tamfum, Jean-Jacques Muyembe ; Belizaire, Marie Roseline Darnycka ; Essomba, René Ghislain ; Assoumou, Marie Claire Okomo ; Mboringong, Akenji Blaise ; Dieng, Alle Baba ; Juozapaitė, Dovilė ; Hosch, Salome ; Obama, Justino ; Ayekaba, Mitoha Ondo'o ; Naumovas, Daniel ; Pautienius, Arnoldas ; Rafaï, Clotaire Donatien ; Vitkauskienė, Astra ; Ugenskienė, Rasa ; Gedvilaitė, Alma ; Čereškevičius, Darius ; Lesauskaitė, Vaiva ; Žemaitis, Lukas ; Griškevičius, Laimonas ; Baele, Guy
DOI	10.1038/s41467-021-26055-8
Full Text
Is Part of	Nature communications.. Berlin : Nature research. 2021, vol. 12, iss. 1, art. no. 5769, p. [1-12].. eISSN 2041-1723
Abstract [eng]	Distinct SARS-CoV-2 lineages, discovered through various genomic surveillance initiatives, have emerged during the pandemic following unprecedented reductions in worldwide human mobility. We here describe a SARS-CoV-2 lineage - designated B.1.620 - discovered in Lithuania and carrying many mutations and deletions in the spike protein shared with widespread variants of concern (VOCs), including E484K, S477N and deletions HV69Δ, Y144Δ, and LLA241/243Δ. As well as documenting the suite of mutations this lineage carries, we also describe its potential to be resistant to neutralising antibodies, accompanying travel histories for a subset of European cases, evidence of local B.1.620 transmission in Europe with a focus on Lithuania, and significance of its prevalence in Central Africa owing to recent genome sequencing efforts there. We make a case for its likely Central African origin using advanced phylogeographic inference methodologies incorporating recorded travel histories of infected travellers.
Published	Berlin : Nature research
Type	Journal article
Language	English
Publication date	2021
CC license

„Emergence and spread of SARS-CoV-2 lineage B.1.620 with variant of concern-like mutations and deletions /“