| Title |
BRCA1/2 mutation status is an independent factor of improved survival for advanced (stage III-IV) ovarian cancer / |
| Authors |
Rudaitis, Vilius ; Žvirblis, Tadas ; Kanopienė, Daiva ; Janulynaitė, Dovilė ; Griškevičius, Laimonas ; Janavičius, Ramūnas |
| DOI |
10.1097/IGC.0000000000000247 |
| Full Text |
|
| Is Part of |
International journal of gynecological cancer.. London : Lippincott Williams & Wilkins, Ltd.. 2014, vol. 24, iss. 8, p. 1395-1400.. ISSN 1048-891X. eISSN 1525-1438 |
| Keywords [eng] |
mutation status ; improved survival ; ovarian cancer |
| Abstract [eng] |
Objective: The aim of this study was to explore BRCA mutation frequency and to evaluate its impact on prognosis of advanced-stage ovarian cancer patients treated with debulking surgery and platinum-based chemotherapy. Methods: Patients with advanced-stage epithelial ovarian cancer were enrolled in a prospective, single-center study from September 2008 to December 2011. All cases were screened for BRCA1 and BRCA2 gene mutations. Progression-free survival (PFS) was assessed between BRCA1/2 mutation carriers and BRCA1/2 wild-type patients. Results: One hundred seven patients were enrolled and screened for BRCA1 and BRCA2 mutations; 51.4% patients were positive for BRCA1/2 gene mutation, 63.6% of which carried a single Baltic mutation, and 98.2% of them had serous histology. Older age (hazard ratio [HR], 1.032; 95% confidence interval [CI], 1.010–1.055; P = 0.0047), nonoptimal cytoreduction (HR, 3.170; 95% CI, 1.986–5.060; P < 0.0001), and BRCA1/2 wild type (HR, 1.625 [1.003–2.632]; P = 0.0486) were significantly associated with shorter PFS in multivariate Cox regression analysis. Only the nonoptimal cytoreduction was a statistically significant risk factor for shorter overall survival (HR, 2.684; 95% CI, 1.264–5.701; P= 0.0102). Conclusions: Advanced ovarian cancer patients harboring BRCA1/2 mutation treated with debulking surgery and platinum-based adjuvant chemotherapy have a longer PFS. |
| Published |
London : Lippincott Williams & Wilkins, Ltd |
| Type |
Journal article |
| Language |
English |
| Publication date |
2014 |
| CC license |
|
