Title Machine perfusion in liver transplantation: a systematic review and meta-analysis /
Authors Jakubauskas, Matas ; Jakubauskienė, Lina ; Leber, Bettina ; Strupas, Kęstutis ; Stiegler, Philipp ; Schemmer, Peter
DOI 10.1159/000519788
Full Text Download
Is Part of Visceral medicine.. Basel : S. Karger AG. 2022, vol. 38, no. 4, p. 243-254.. ISSN 2297-4725. eISSN 2297-475X
Keywords [eng] Extended criteria donors ; liver transplantation ; machine perfusion ; marginal grafts
Abstract [eng] Background: Liver transplantation (LTx) is the only treatment option for patients with end-stage liver disease. Novel organ preservation techniques such as hypothermic machine perfusion (HMP) or normothermic machine perfusion (NMP) are under investigation in order to improve organ quality from extended criteria donors and donors after circulatory death. The aim of this study was to systematically review the literature reporting LTx outcomes using NMP or HMP compared to static cold storage (SCS). Methods: The following data were retrieved: graft primary nonfunction rate, early allograft dysfunction (EAD) rate, biliary complication rate, and 12-month graft and patient survival. A total of 15 studies were included (6 NMP and 9 HMP studies), and meta-analysis was performed only for HMP studies because NMP had considerable differences. Results: The systematic review showed the potential of NMP to reduce graft injury and lower the liver graft discard rate. The performed quantitative analyses showed that the use of HMP reduces the rate of EAD (odds ratio [OR] 0.51; 95% confidence interval [CI] 0.34-0.76; p = 0.001; I2 = 0%) and non-anastomotic biliary strictures (OR 0.34; 95% CI 0.17-0.67; p = 0.002; I2 = 0%) compared to SCS. Conclusion: Our systematic review and meta-analysis revealed that the use of HMP reduces the rate of EAD and non-anastomotic biliary strictures compared to SCS.
Published Basel : S. Karger AG
Type Journal article
Language English
Publication date 2022
CC license CC license description