Obesity and the risk of cryptogenic ischemic stroke in young adults /

Nina Jaakonmäki; Marialuisa Zedde; Tomi Sarkanen; Nicolas Martinez-Majander; Suvi Tuohinen; Juha Sinisalo; Essi Ryödi; Jaana Autere; Marja Hedman; Ulla Junttola; Jaana K Huhtakangas; Teresa Grimaldi; Rosario Pascarella; Annika Nordanstig; Odd Bech-Hanssen; Christine Holbe; Raila Busch; Annette Fromm; Pauli Ylikotila; Esme Ekizoglu Turgut; Isabel Amorim; Kristina Ryliškienė; Lauri Tulkki; Laura Amaya Pascasio; Radim Licenik; Phillip Ferdinand; Georgios Tsivgoulis; Dalius Jatužis; Liisa Kõrv; Janika Kõrv; Alessandro Pezzini; Ana Catarina Fonseca; Nilufer Yesilot; Risto O Roine; Ulrike Waje-Andreassen; Bettina von Sarnowski; Petra Redfors; Juha Huhtakangas; Heikki Numminen; Pekka Jäkälä; Jukka Putaala

doi:10.1016/j.jstrokecerebrovasdis.2022.106380

Title	Obesity and the risk of cryptogenic ischemic stroke in young adults /
Authors	Jaakonmäki, Nina ; Zedde, Marialuisa ; Sarkanen, Tomi ; Martinez-Majander, Nicolas ; Tuohinen, Suvi ; Sinisalo, Juha ; Ryödi, Essi ; Autere, Jaana ; Hedman, Marja ; Junttola, Ulla ; Huhtakangas, Jaana K ; Grimaldi, Teresa ; Pascarella, Rosario ; Nordanstig, Annika ; Bech-Hanssen, Odd ; Holbe, Christine ; Busch, Raila ; Fromm, Annette ; Ylikotila, Pauli ; Turgut, Esme Ekizoglu ; Amorim, Isabel ; Ryliškienė, Kristina ; Tulkki, Lauri ; Pascasio, Laura Amaya ; Licenik, Radim ; Ferdinand, Phillip ; Tsivgoulis, Georgios ; Jatužis, Dalius ; Kõrv, Liisa ; Kõrv, Janika ; Pezzini, Alessandro ; Fonseca, Ana Catarina ; Yesilot, Nilufer ; Roine, Risto O ; Waje-Andreassen, Ulrike ; von Sarnowski, Bettina ; Redfors, Petra ; Huhtakangas, Juha ; Numminen, Heikki ; Jäkälä, Pekka ; Putaala, Jukka
DOI	10.1016/j.jstrokecerebrovasdis.2022.106380
Full Text
Is Part of	Journal of stroke and cerebrovascular diseases.. Amsterdam : Elsevier Science. 2022, vol. 31, no. 5, art. no. 106380, p. [1-9].. ISSN 1052-3057. eISSN 1532-8511
Keywords [eng]	cryptogenic stroke ; ischemic stroke ; obesity ; waist-to-hip ratio ; young adults
Abstract [eng]	Objectives: We examined the association between obesity and early-onset crypto- genic ischemic stroke (CIS) and whether fat distribution or sex altered this associa- tion. Materials and Methods: This prospective, multi-center, case-control study included 345 patients, aged 18-49 years, with first-ever, acute CIS. The control group included 345 age- and sex-matched stroke-free individuals. We measured height, weight, waist circumference, and hip circumference. Obesity metrics ana- lyzed included body mass index (BMI), waist-to-hip ratio (WHR), waist-to-stature ratio (WSR), and a body shape index (ABSI). Models were adjusted for age, level of education, vascular risk factors, and migraine with aura. Results: After adjusting for demographics, vascular risk factors, and migraine with aura, the highest tertile of WHR was associated with CIS (OR for highest versus lowest WHR tertile 2.81, 95%CI 1.43-5.51; P=0.003). In sex-specific analyses, WHR tertiles were not associ- ated with CIS. However, using WHO WHR cutoff values (>0.85 for women, >0.90 for men), abdominally obese women were at increased risk of CIS (OR 2.09, 95%CI 1.02-4.27; P=0.045). After adjusting for confounders, WC, BMI, WSR, or ABSI were not associated with CIS. Conclusions: Abdominal obesity measured with WHR was an independent risk factor for CIS in young adults after rigorous adjustment for concomitant risk factors.
Published	Amsterdam : Elsevier Science
Type	Journal article
Language	English
Publication date	2022
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„Obesity and the risk of cryptogenic ischemic stroke in young adults /“