| Title |
The impact of probiotics on intestinal mucositis during chemotherapy for colorectal cancer. a comprehensive review of animal studies / |
| Authors |
Miknevičius, Povilas ; Žulpaitė, Rūta ; Leber, Bettina ; Strupas, Kęstutis ; Stiegler, Philipp ; Schemmer, Peter |
| DOI |
10.3390/ijms22179347 |
| Full Text |
|
| Is Part of |
International journal of molecular sciences.. Basel : MDPI. 2021, vol. 22, no. 17, art no. 9347, p. [1-16].. ISSN 1661-6596. eISSN 1422-0067 |
| Keywords [eng] |
dysbiosis ; gut microbiota ; proinflammatory cytokines |
| Abstract [eng] |
Colorectal cancer (CRC) is the second most commonly diagnosed cancer in females (inci-dence 16.4/10000) and the third in males (incidence 23.4/10000) worldwide. Surgery, chemotherapy (CTx), radiation therapy (RTx), or a combined treatment of those are the current treatment modali-ties for primary CRC. Chemotherapeutic drug-induced gastrointestinal (GIT) toxicity mainly pre-sents as mucositis and diarrhea. Preclinical studies revealed that probiotic supplementation helps prevent CTx-induced side effects by reducing oxidative stress and proinflammatory cytokine production and promoting crypt cell proliferation. Moreover, probiotics showed significant results in preventing the loss of body weight (BW) and reducing diarrhea. However, further clinical studies are needed to elucidate the exact doses and most promising combination of strains to reduce or prevent chemotherapy-induced side effects. The aim of this review is to overview currently available literature on the impact of probiotics on CTx-induced side effects in animal studies concerning CRC treatment and discuss the potential mechanisms based on experimental studies’ outcomes. |
| Published |
Basel : MDPI |
| Type |
Journal article |
| Language |
English |
| Publication date |
2021 |
| CC license |
|
