Title Efficacy and safety of armolipid plus®: an updated prisma compliant systematic review and meta-analysis of randomized controlled clinical trials
Authors Cicero, Arrigo F. G ; Kennedy, Cormac ; Knežević, Tamara ; Bove, Marilisa ; Georges, Coralie M. G ; Šatrauskienė, Agnė ; Toth, Peter P ; Fogacci, Federica
DOI 10.3390/nu13020638
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Is Part of Nutrents.. Basel : MDPI. 2021, vol. 13, no. 2, art. no. 638, p. [1-17].. eISSN 2072-6643
Keywords [eng] armolipid Plus® ; berberine ; blood pressure ; fasting plasma glucose ; lipids ; nutraceutical ; red yeast rice ; supplementation
Abstract [eng] Armolipid Plus® is a multi-constituent nutraceutical that claims to improve lipid profiles. The aim of this PRISMA compliant systematic review and meta-analysis was to globally evaluate the efficacy and safety of Armolipid Plus® on the basis of the available randomized, blinded, controlled clinical trials (RCTs). A systematic literature search in several databases was conducted in order to identify RCTs assessing the efficacy and safety of dietary supplementation with Armolipid Plus®. Two review authors independently identified 12 eligible studies (1050 included subjects overall) and extracted data on study characteristics, methods, and outcomes. Meta-analysis of the data suggested that dietary supplementation with Armolipid Plus® exerted a significant effect on body mass index (mean difference (MD) = −0.25 kg/m2, p = 0.008) and serum levels of total cholesterol (MD = −25.07 mg/dL, p < 0.001), triglycerides (MD = −11.47 mg/dL, p < 0.001), high-density lipoprotein cholesterol (MD = 1.84 mg/dL, p < 0.001), low-density lipoprotein cholesterol (MD = −26.67 mg/dL, p < 0.001), high sensitivity C reactive protein (hs-CRP, MD = −0.61 mg/L, p = 0.022), and fasting glucose (MD = −3.52 mg/dL, p < 0.001). Armolipid Plus® was well tolerated. This meta-analysis demonstrates that dietary supplementation with Armolipid Plus® is associated with clinically meaningful improvements in serum lipids, glucose, and hs-CRP. These changes are consistent with improved cardiometabolic health.
Published Basel : MDPI
Type Journal article
Language English
Publication date 2021
CC license CC license description