| Abstract [eng] |
Prostate cancer is known to exhibit the immunosuppressive tumor microenvironment. Surgery also suppresses anti-tumor immunity, allowing circulating cancer cells to survive. Tumor removal should disrupt the systemic and local immunity communication. The question arises whether this disruption might be reflected in the phenotypic alteration of the peripheral blood lymphocytes. We compared the patterns of immunophenotypic variations occurring in blood of patients following open and laparoscopic prostatectomies. We assessed the relationship between immunophenotype changes and clinical data (Gleason score, stage, positive margin, lympho-node status) as well as the risk of biochemical recurrence. We found, that Laparoscopic Radical Prostatectomy (LPR) technique resulted in complete restoration of T cell, NK, CTL. Also the immunosuppressive compartment (MDSC) did not reveal any upregulation in the postoperative period once the LPR technique was applied, Conversely, Open Radical Prostatectomy (ORP) was associated with the absence of CTL postoperative restoration as well as the suppressor compartment (MDSC) increase in the postoperative period. An integrated two-parameter (ePSA plus immunophenotype) benchmark was assessed in order to unveil the best applicable BCR prognosticator suitable for a 32-month postoperative follow-up. |
