Title Extracellular photovoltage clamp using conducting polymer-modified organic photocapacitors /
Authors Silvera Ejneby, Malin ; Migliaccio, Ludovico ; Gicevičius, Mindaugas ; Derek, Vedran ; Jakesova, Marie ; Elinder, Fredrik ; Glowacki, Eric Daniel
DOI 10.1002/admt.201900860
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Is Part of Advanced materials technologies: Special issue: Bioelectronics.. Hoboken : Wiley. 2020, vol. 5, iss. 3, art. no. 1900860, p. [1-9].. ISSN 2365-709X
Keywords [eng] cellular photostimulation ; electrophysiology ; organic bioelectronics ; organic photovoltaics ; PEDOT ; PSS
Abstract [eng] Optoelectronic control of physiological processes accounts for new possibilities ranging from fundamental research to treatment of disease. Among nongenetic light-driven approaches, organic semiconductor-based device platforms such as the organic electrolytic photocapacitor (OEPC) offer the possibility of localized and wireless stimulation with a minimal mechanical footprint. Optimization of efficiency hinges on increasing effective capacitive charge delivery. Herein, a simple strategy to significantly enhance the photostimulation performance of OEPC devices by employing coatings of the conducting polymer formulation poly(3,4-ethylenedioxythiophene):poly(styrene sulfonate), or PEDOT:PSS is reported. This modification increases the charge density of the stimulating photoelectrodes by a factor of 2-3 and simultaneously decreases the interfacial impedance. The electrophysiological effects of PEDOT:PSS-derivatized OEPCs on Xenopus laevis oocyte cells on membrane potential are measured and voltage-clamp techniques are used, finding an at-least twofold increase in capacitive coupling. The large electrolytic capacitance of PEDOT:PSS allows the OEPC to locally alter the extracellular voltage and keep it constant for long periods of time, effectively enabling a unique type of light-controlled membrane depolarization for measurements of ion channel opening. The finding that PEDOT:PSS-coated OEPCs can remain stable after a 50-day accelerated ageing test demonstrates that PEDOT:PSS modification can be applied for fabricating reliable and efficient optoelectronic stimulation devices.
Published Hoboken : Wiley
Type Journal article
Language English
Publication date 2020
CC license CC license description