| Abstract [eng] |
Incidence of cervical cancer in Lithuania is one of the largest in Europe. Approximately in 50% of the cases locally advanced cervical cancer is diagnosed, despite screening programme. In order to more effectively diagnose and treat this disease, it is necessary to deepen knowledge about cervical cancer development mechanisms, identify markers that could help identify individuals with an increased risk of cervical cancer and to individualize treatment, choosing the most effective treatment method. Aim of the study - to assess the importance of molecular (reduced glutathione (GSH) and glutathione S-transferase (GST)) and genetic (glutathione S-transferase (GST) genes polymorphism) factors determining the activity of antioxidative system for development of cervical cancer and evaluate the role of these factors during the treatment of locally advanced cervical cancer by means of neoadjuvant chemotherapy and chemoradiotherapy. In our study significant differences in blood serum levels of GSH and GST in patients with locally advanced cervical cancer, women with cervical intraepithelial lesions and healthy women demonstrated the importance of antioxidative system΄s components in cervical carcinogenesis and the changes in GSH levels in the process of the treatment of locally advanced cervical cancer can be significant for predicting of the treatment effectiveness. Taking into account statistically significant incidence of deletions in GSTM1 and GSTT1 genes among these groups, it can be stated, that in event of polymorphism of genes mentioned above, the probability to develop cervical cancer is higher. This study may be useful in selecting groups of women at high risk of developing cervical cancer. |
