Title Early bilateral gonadoblastoma in a patient with mixed gonadal dysgenesis (karyotype 45,X/46,XY): case report and review of literature /
Authors Trainavičius, Ignas ; Dasevičius, Darius ; Burnytė, Birutė ; Kemežys, Robertas ; Verkauskas, Gilvydas
DOI 10.15388/Amed.2022.29.2.5
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Is Part of Acta medica Lituanica.. Vilnius : Vilniaus universiteto leidykla. 2022, vol. 29, no. 2, p. 194-200.. ISSN 1392-0138. eISSN 2029-4174
Keywords [eng] Disorders of sex development ; gonadal dysgenesis ; mixed gonadal dysgenesis ; 45,X/46,XY mosaicism ; gonadoblastoma ; gonadectomy
Abstract [eng] Background: Mixed gonadal dysgenesis is a rare congenital and challenging condition, characterized mainly by 45,X/46,XY karyotype mosaicism, asymmetrical gonadal development and various internal and external genital anatomy. Because of frequent disorder of genital development and a higher risk of germ cell neoplasia, management of these patients is complex and requires multidisciplinary approach. Case: We present a 45,X/46,XY mixed gonadal dysgenesis patient diagnosed with gonadoblastoma in both gonads after bilateral gonadectomy at 1 year of age. Conclusions: Because of high risk for malignant transformation, gonadectomy of a streak-like gonad and biopsy with orchidopexy or gonadectomy of a dysgenetic testicle is recommended at an early age.
Published Vilnius : Vilniaus universiteto leidykla
Type Journal article
Language English
Publication date 2022
CC license CC license description