| Title |
Caudovirales bacteriophages are associated with improved executive function and memory in flies, mice, and humans / |
| Authors |
Mayneris-Perxachs, Jordi ; Castells-Nobau, Anna ; Arnoriaga-Rodríguez, María ; Garre-Olmo, Josep ; Puig, Josep ; Ramos, Rafael ; Martínez-Hernández, Francisco ; Burokas, Aurelijus ; Coll, Clàudia ; Moreno-Navarrete, José Maria ; Zapata-Tona, Cristina ; Pedraza, Salvador ; Pérez-Brocal, Vicente ; Ramió-Torrentà, Lluís ; Ricart, Wifredo ; Moya, Andrés ; Martínez-García, Manuel ; Maldonado, Rafael ; Fernández-Real, José-Manuel |
| DOI |
10.1016/j.chom.2022.01.013 |
| Full Text |
|
| Is Part of |
Cell host & microbe.. Cambridge, MA : Cell Press. 2022, vol. 30, iss. 3, p. 340-356; e1-e8.. ISSN 1931-3128. eISSN 1934-6069 |
| Keywords [eng] |
Drosophila ; bacteriophages ; brain ; cognition ; fecal transplantation ; human ; memory ; mice. |
| Abstract [eng] |
Growing evidence implicates the gut microbiome in cognition. Viruses, the most abundant life entities on the planet, are a commonly overlooked component of the gut virome, dominated by the Caudovirales and Microviridae bacteriophages. Here, we show in a discovery (n = 114) and a validation cohort (n = 942) that subjects with increased Caudovirales and Siphoviridae levels in the gut microbiome had better performance in executive processes and verbal memory. Conversely, increased Microviridae levels were linked to a greater impairment in executive abilities. Microbiota transplantation from human donors with increased specific Caudovirales (>90% from the Siphoviridae family) levels led to increased scores in the novel object recognition test in mice and up-regulated memory-promoting immediate early genes in the prefrontal cortex. Supplementation of the Drosophila diet with the 936 group of lactococcal Siphoviridae bacteriophages resulted in increased memory scores and upregulation of memory-involved brain genes. Thus, bacteriophages warrant consideration as novel actors in the microbiome-brain axis. |
| Published |
Cambridge, MA : Cell Press |
| Type |
Journal article |
| Language |
English |
| Publication date |
2022 |
| CC license |
|
