| Title |
Chemoimunoterapijos efektyvumo vertinimas pelių navikų modeliuose, pasižyminčiuose skirtingu antigeno apdorojimo ir pateikimo mechanizmo funkcionalumu / |
| Translation of Title |
Evaluation of chemoimmunotherapy efficacy in murine tumor models with different antigen processing and presentation mechanism functionality. |
| Authors |
Žilionytė, Karolina |
| DOI |
10.15388/vu.thesis.378 |
| Full Text |
|
| Pages |
184 |
| Keywords [eng] |
immunotherapy ; chemotherapy ; cancer ; MHC-I ; Ag processing and presentation mechanism |
| Abstract [eng] |
Immunotherapy is a promising cancer treatment that stimulates patient's immune system to fight against tumor cells. Clinical results of immunotherapy reveal that patient response to immunotherapy is heterogeneous and often low. To improve the effectiveness of immunotherapy, it is necessary to identify possible resistance mechanisms, predictive biomarkers for treatment personalization and effective combinatorial treatment strategies. In this thesis, using mouse tumor models, the influence of antigen processing and presentation mechanism functionality in tumor cells on the efficacy of T-lymphocyte-based immunotherapy is demonstrated. The predictive value of the expression of genes related to the mechanism of antigen processing and presentation in the individualization of treatment with dendritic cell vaccines and anti-PD-1 is also revealed. The results obtained during the study show that the functionality of the antigen processing and presentation mechanism can be modulated by the chemotherapeutic drug cyclophosphamide. The activating effect of cyclophosphamide on the antigen processing and presentation mechanism may make tumor cells more immunogenic and thus pave the way for T-lymphocyte-based immunotherapy. |
| Dissertation Institution |
Vilniaus universitetas. |
| Type |
Doctoral thesis |
| Language |
Lithuanian |
| Publication date |
2022 |
