Psilocybin - mediated attenuation of gamma band auditory steady-state responses (ASSR) is driven by the intensity of cognitive and emotional domains of psychedelic experience /

Vojtěch Viktorin; Inga Griškova-Bulanova; Aleksandras Voicikas; Dominika Dojčánová; Peter Zach; Anna Bravermanová; Veronika Andrashko; Filip Tylš; Jakub Korčák; Michaela Viktorinová; Vlastimil Koudelka; Kateřina Hájková; Martin Kuchař; Jiří Horáček; Martin Brunovský; Tomáš Páleníček

doi:10.3390/jpm12061004

Title	Psilocybin - mediated attenuation of gamma band auditory steady-state responses (ASSR) is driven by the intensity of cognitive and emotional domains of psychedelic experience /
Authors	Viktorin, Vojtěch ; Griškova-Bulanova, Inga ; Voicikas, Aleksandras ; Dojčánová, Dominika ; Zach, Peter ; Bravermanová, Anna ; Andrashko, Veronika ; Tylš, Filip ; Korčák, Jakub ; Viktorinová, Michaela ; Koudelka, Vlastimil ; Hájková, Kateřina ; Kuchař, Martin ; Horáček, Jiří ; Brunovský, Martin ; Páleníček, Tomáš
DOI	10.3390/jpm12061004
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Is Part of	Journal of personalized medicine.. Basel : MDPI. 2022, vol. 12, iss. 6, art. no. 1004, p. [1-13].. eISSN 2075-4426
Keywords [eng]	auditory steady-state response ; EEG ; model of psychosis ; psilocybin ; psychedelics ; serotonin
Abstract [eng]	Psilocybin is a classical serotoninergic psychedelic that induces cognitive disruptions similar to psychosis. Gamma activity is affected in psychosis and is tightly related to cognitive processing. The 40 Hz auditory steady-state responses (ASSR) are frequently used as indicators to test the ability to generate gamma activity. Based on previous literature, we studied the impact of psilocybin on 40 Hz ASSR in healthy volunteers. The study was double blind and placebo controlled with a crossover design. A sample of 20 healthy subjects (10M/10F) received psilocybin orally 0.26 mg/kg or placebo. Participants were measured four times in total, one time before ingestion of psilocybin/placebo and one time after ingestion, during the peak of intoxication. A series of 500 ms click trains were used for stimulation. Psilocybin induced a psychedelic effect and decreased 40 Hz ASSR phase-locking index compared to placebo. The extent of the attenuation was related to Cognition and Affect on the Hallucinogen Rating Scale. The current study shows that psilocybin lowers the synchronization level and the amplitude of 40 Hz auditory steady-state responses, which yields further support for the role of gamma oscillations in cognitive processing and its disturbance.
Published	Basel : MDPI
Type	Journal article
Language	English
Publication date	2022
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„Psilocybin - mediated attenuation of gamma band auditory steady-state responses (ASSR) is driven by the intensity of cognitive and emotional domains of psychedelic experience /“