Title Prehabilitation in modern colorectal cancer surgery: a comprehensive review /
Authors Baušys, Augustinas ; Kryžauskas, Marius ; Abeciūnas, Vilius ; Degutytė, Austėja Elžbieta ; Baušys, Rimantas ; Strupas, Kęstutis ; Poškus, Tomas
DOI 10.3390/cancers14205017
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Is Part of Cancers.. Basel : MDPI. 2022, vol. 14, iss. 20, art. no. 5017, p. [1-20].. eISSN 2072-6694
Keywords [eng] colon cancer ; rectal cancer ; colorectal cancer ; prehabilitation ; exercise ; surgical outcomes
Abstract [eng] Colorectal cancer remains the third most prevalent cancer worldwide, exceeding 1.9 million new cases annually. Surgery continues to be the gold standard treatment option. Unfortunately, colorectal cancer surgery carries significant postoperative morbidity and mortality. Moreover, most rectal cancer patients and some patients with locally advanced colon cancer require preoperative neoadjuvant therapy. It improves long-term outcomes but impairs patients’ physical fitness and thus further increases surgical risk. Recently, prehabilitation has gained interest as a novel strategy to reduce treatment-related morbidity for patients undergoing colorectal cancer surgery. However, the concept is still in its infancy, and the role of prehabilitation remains controversial. In this comprehensive review, we sum up present evidence on prehabilitation before colorectal cancer surgery. Available studies are very heterogenous in interventions and investigated outcomes. Nonetheless, all trials show at least some positive effects of prehabilitation on patients’ physical, nutritional, or psychological status or even reduced postoperative morbidity. Unfortunately, the optimal prehabilitation program remains undetermined; therefore, this concept cannot be widely implemented. Future studies investigating optimal prehabilitation regimens for patients undergoing surgery for colorectal cancer are necessary.
Published Basel : MDPI
Type Journal article
Language English
Publication date 2022
CC license CC license description