| Abstract [eng] |
As morbidity of skin melanoma increases, its early diagnosis and treatment become a most important goal. According to the data from clinical studies, dysplastic nevus is associated with elevated melanoma risks in three aspects: it shares similar features with melanoma, it is a melanoma risk marker and it is a possible precursor of melanoma. An accurate diagnosis of dysplastic nevus and skin melanoma is important to lower mortality and morbidity rates of skin melanoma. The progress of medical science provides new non-invasive diagnostic possibilities. In vivo reflectance confocal microscopy offers live examination of skin morphology at the cellular level. Hence, the aim of this study is to define the accuracy of in vivo reflectance confocal microscopy in the diagnosis of dysplastic melanocytic nevus and skin melanoma. The results of the study confirmed that features of melanocytic skin lesions examined by in vivo reflectance confocal microscopy correspond to features of cellular atypia in an histological examination. Sensitivity and specificity of in vivo reflectance confocal microscopy in the diagnosis of dysplastic nevi is insufficient to distinguish dysplastic nevi from common nevi, but the accuracy of in vivo reflectance confocal microscopy is significant in diagnosis of skin melanoma. Since the in vivo reflectance confocal microscopy examination improves the accuracy of skin melanoma diagnosis, it should be used when atypia of nevus is detected or skin melanoma is suspected. |
