| Title |
Development of a new voltammetric method for aceclofenac determination on glassy carbon electrode modified with hierarchical nanocomposite / |
| Authors |
Górska, Anna ; Paczosa-Bator, Beata ; Gaidukevič, Justina ; Piech, Robert |
| DOI |
10.3390/s22228954 |
| Full Text |
|
| Is Part of |
Sensors: The design, fabrication and sensor applications of nano-electrodes.. Basel : MDPI. 2022, vol. 22, iss. 22, art. no. 8954, p. 1-14.. eISSN 1424-8220 |
| Keywords [eng] |
aceclofenac ; metal nanoparticles ; voltammetry ; carbon nanomaterials |
| Abstract [eng] |
Aceclofenac (ACL) is an anti-inflammatory drug, which is taken by patients who mainly suffer from rheumatoid conditions. In this work, we propose a new voltammetric method that allows the determination of ACL in pharmaceutics, urine, and plasma. As a working electrode, a glassy carbon electrode (GCE) modified with carbon nanofibers, carbon nanotubes, and NiCo nanoparticles (eCNF/CNT/NiCo-GCE) was used. The mentioned sensors are characterized by good repeatability and sensitivity, and their process of preparation is simple, fast, and cost-effective. Instrumental and method parameters were optimized, and the influence of interferences was investigated. To validate the analytical performance of the method, calibration was conducted. Good linearity was obtained (0.05–1.4 µM, r = 0.998), as well as excellent limit of detection (LOD) and limit of quantification (LOQ) values (0.7 nM and 2.1 nM, respectively). Calculated recoveries that were in the range of 98%–105% indicate that this method is accurate and might be used in routine laboratory practice. |
| Published |
Basel : MDPI |
| Type |
Journal article |
| Language |
English |
| Publication date |
2022 |
| CC license |
|
