| Title |
Prevalence and variability of allergen-specific immunoglobulin E in patients with elevated tryptase levels / |
| Authors |
Černiauskienė, Megė ; Bagdonaitė, Loreta ; Karčiauskaitė, Dovilė ; Kvedarienė, Violeta |
| DOI |
10.12659/MSM.937990 |
| Full Text |
|
| Is Part of |
Medical science monitor.. Melville : Medical Science International. 2022, vol. 28, art. no. e937990, p. [1-7].. ISSN 1643-3750. eISSN 1643-3750 |
| Keywords [eng] |
allergens ; anaphylaxis ; mastocytosis ; tryptases |
| Abstract [eng] |
Background: In this paper we report on the link between increased tryptase levels and prevalence of allergen-specific immunoglobulin E (IgE) in patients with anaphylaxis. The main aim of the study was to assess the corelation between elevated tryptase levels and allergen-specific immunoglobulin E (IgE) in anaphylactic reactions, mastocytosis, and other types of allergic reactions. Material/Methods: We enrolled 60 adult patients, aged 18-68 years (mean age 45±8 years). The subjects were divided into 3 groups (20 patients in each group) according to the serum tryptase changes: group 1 consisted of patients with anaphylaxis (serum tryptase level ³11.4 μg/l), group 2 consisted of patients with mastocytosis (serum tryptase level ³20.0 μg/l), and group 3 consisted of patients with other allergic reactions with no anaphylaxis as an atopic control group (serum tryptase level <11.4 μg/l). The test material was venous blood serum samples. The allergen- specific IgE assay was carried out by immunoblot. Tryptase concentration was determined by immunoenzymatic assay. Results: Allergen-specific IgE was found in 73% of all subjects: 75% in the anaphylactic group, 55% in the mastocytosis group, and 90% in the atopic control group. Polysensitization was common and was significantly different among groups. In the atopic group, there were more patients allergic to 4-7 allergens (P<0.05). Conclusions: We did not find a strong correlation between allergen-specific IgE levels and elevated tryptase levels. |
| Published |
Melville : Medical Science International |
| Type |
Journal article |
| Language |
English |
| Publication date |
2022 |
| CC license |
|
