Sex differences in COVID-19 mortality risk in patients on kidney function replacement therapy /

Priya Vart; Raphaël Duivenvoorden; Aaltje Adema; Adrian Covic; Patrik Finne; Nicole Heijtink-ter Braak; Kaisa Laine; Marlies Noordzij; Marcel Schouten; Kitty J Jager; Ron T Gansevoort; Jeroen B van der Net; Marie Essig; Peggy W. G du Buf-Vereijken; Betty van Ginneken; Nanda Maas; Brigit C van Jaarsveld; Frederike J Bemelman; Farah Klingenberg-Salahova; Frederiek Heenan-Vos; Marc G Vervloet; Azam Nurmohamed; Liffert Vogt; Daniel Abramowicz; Sabine Verhofstede; Omar Maoujoud; Thomas Malfait; Jana Fialova; Edoardo Melilli; Alexandre Favà; Josep M Cruzado; Nuria Montero Perez; Joy Lips; Harmen Krepel; Harun Adilovic; Daniela Radulescu; Maaike Hengst; Constantijn Konings; Andrzej Rydzewski; Philippe Braconnier; Daniel Weis; Ryszard Gellert; João Oliveira; Daniela G Alferes; Elena V Zakharova; Patrice Max Ambühl; Rebecca Guidotti; Andrea Walker; Fanny Lepeytre; Clémentine Rabaté; Guy Rostoker; Sofia Marques; Tijana Azasevac; Gordana Strazmester Majstorovic; Dajana Katicic; Marc ten Dam; Thilo Krüger; Szymon Brzosko; Vassilios Liakopoulos; Adriaan L Zanen; Susan J. J Logtenberg; Lutz Fricke; Olexandr Kuryata; Jeroen J. P Slebe; Samar Abd ElHafeez; Delphine Kemlin; Jacqueline van de Wetering; Marlies E. J Reinders; Dennis A Hesselink; J Kal-van Gestel; Jaromir Eiselt; Lukas Kielberger; Hala S El-Wakil; Martine Verhoeven; Ian Logan; Cristina Canal; Carme Facundo; Ana M Ramos; Alicja Debska-Slizien; Nicoline M. H Veldhuizen; Eirini Tigka; Maria Anna Polyzou Konsta; Stylianos Panagoutsos; Francesca Mallamaci; Adele Postorino; Francesco Cambareri; Irina Matceac; Ionut Nistor; J. H.M Groeneveld; Jolanda Jousma; Marjolijn van Buren; Fritz Diekmann; Federico Oppenheimer; Miquel Blasco; Tiago Assis Pereira; Augusto Cesar S Santos; Carlos Arias-Cabrales; Marta Crespo; Laura Llinàs-Mallol; Anna Buxeda; Carla Burballa Tàrrega; Dolores Redondo-Pachon; Maria Dolores Arenas Jimenez; Alberto Mendoza-Valderrey; Ana Cristina Martins; Catarina Mateus; Goncalo Alvila; Ivo Laranjinha; Julia M Hofstra; Machiel A Siezenga; Antonio Franco; David Arroyo; Sandra Castellano; Maria Luisa Rodríguez-Ferrero; Sagrario Balda Manzanos; R. Haridian Sosa Barrios; Wim Lemahieu; Karlijn Bartelet; Ahmet Burak Dirim; Erol Demir; Mehmet Sukru Sever; Aydin Turkmen; Seda Şafak; Daan A. M. J Hollander; Stefan Büttner; Aiko P. J de Vries; Soufian Meziyerh; Danny van der Helm; Marko Mallat; Hanneke Bouwsma; Sivakumar Sridharan; Kristina Petrulienė; Sharon-Rose Maloney; Iris Verberk; Frank M van der Sande; Maarten H. L Christiaans; Marc H Hemmelder; N MohanKumar; Marina Di Luca; Serhan Z Tuğlular; Andrea B Kramer; Charles Beerenhout; Peter T Luik; Julia Kerschbaum; Martin Tiefenthaler; Bruno Watschinger; Vadim A Stepanov; Alexey B Zulkarnaev; Kultigin Turkmen; Ilaria Gandolfini; Umberto Maggiore; Anselm Fliedner; Anders Åsberg; Geir Mjoen; Hitoshi Miyasato; Carola W. H de Fijter; Nicola Mongera; Stefano Pini; Consuelo de Biase; Angele Kerckhoffs; Anne Els van de Logt; Rutger Maas; Luuk B Hilbrands; Olga Lebedeva; Veronica Lopez; Louis J. M Reichert; Jacobien Verhave; Denis Titov; Ekaterina V Parshina; Luca Zanoli; Carmelita Marcantoni; Gijs van Kempen; Liesbeth E. A van Gils-Verrij; John C Harty; Marleen Meurs; Marek Myslak; Yuri Battaglia; Paolo Lentini; Edwin den Deurwaarder; Maria Stendahl; Hormat Rahimzadeh; Ivan Rychlik; Carlos J Cabezas-Reina; Ana Maria Roca; Ferdau Nauta; İdris Sahin; Eric Goffin; Nada Kanaan; Laura Labriola; Arnaud Devresse; Anabel Diaz-Mareque; Armando Coca; Gabriel de Arriba; Björn K. I Meijers; Maarten Naesens; Dirk Kuypers; Bruno Desschans; Annelies Tonnerlier; Karl M Wissing; Ivana Dedinska; Giuseppina Pessolano; Shafi Malik; Evangelia Dounousi; Evangelos Papachristou; Stefan P Berger; Jan Stephan F Sanders; Casper F. M Franssen; Akin Özyilmaz; Jadranka Buturović Ponikvar; Andreja Marn Pernat; Damjan Kovac; Miha Arnol; Robert Ekart; Alferso C Abrahams; Femke M Molenaar; Arjan D van Zuilen; Sabine C. A Meijvis; Helma Dolmans; Ekamol Tantisattamo; Pasquale Esposito; Jean-Marie Krzesinski; Jean Damacène Barahira; Maurizio Gallieni; Paloma Leticia Martin-Moreno; Gabriele Guglielmetti; Gabriella Guzzo; Nestor Toapanta; Maria Jose Soler; Antinus J Luik; Willi H. M van Kuijk; Lonneke W. H Stikkelbroeck; Marc M. H Hermans; Laurynas Rimševičius; Marco Righetti; Mahmud Islam

doi:10.1038/s41598-022-22657-4

Title	Sex differences in COVID-19 mortality risk in patients on kidney function replacement therapy /
Authors	Vart, Priya ; Duivenvoorden, Raphaël ; Adema, Aaltje ; Covic, Adrian ; Finne, Patrik ; Braak, Nicole Heijtink-ter ; Laine, Kaisa ; Noordzij, Marlies ; Schouten, Marcel ; Jager, Kitty J ; Gansevoort, Ron T ; van der Net, Jeroen B ; Essig, Marie ; du Buf-Vereijken, Peggy W. G ; van Ginneken, Betty ; Maas, Nanda ; van Jaarsveld, Brigit C ; Bemelman, Frederike J ; Klingenberg-Salahova, Farah ; Heenan-Vos, Frederiek ; Vervloet, Marc G ; Nurmohamed, Azam ; Vogt, Liffert ; Abramowicz, Daniel ; Verhofstede, Sabine ; Maoujoud, Omar ; Malfait, Thomas ; Fialova, Jana ; Melilli, Edoardo ; Favà, Alexandre ; Cruzado, Josep M ; Perez, Nuria Montero ; Lips, Joy ; Krepel, Harmen ; Adilovic, Harun ; Radulescu, Daniela ; Hengst, Maaike ; Konings, Constantijn ; Rydzewski, Andrzej ; Braconnier, Philippe ; Weis, Daniel ; Gellert, Ryszard ; Oliveira, João ; Alferes, Daniela G ; Zakharova, Elena V ; Ambühl, Patrice Max ; Guidotti, Rebecca ; Walker, Andrea ; Lepeytre, Fanny ; Rabaté, Clémentine ; Rostoker, Guy ; Marques, Sofia ; Azasevac, Tijana ; Majstorovic, Gordana Strazmester ; Katicic, Dajana ; ten Dam, Marc ; Krüger, Thilo ; Brzosko, Szymon ; Liakopoulos, Vassilios ; Zanen, Adriaan L ; Logtenberg, Susan J. J ; Fricke, Lutz ; Kuryata, Olexandr ; Slebe, Jeroen J. P ; ElHafeez, Samar Abd ; Kemlin, Delphine ; van de Wetering, Jacqueline ; Reinders, Marlies E. J ; Hesselink, Dennis A ; Kal-van Gestel, J ; Eiselt, Jaromir ; Kielberger, Lukas ; El-Wakil, Hala S ; Verhoeven, Martine ; Logan, Ian ; Canal, Cristina ; Facundo, Carme ; Ramos, Ana M ; Debska-Slizien, Alicja ; Veldhuizen, Nicoline M. H ; Tigka, Eirini ; Konsta, Maria Anna Polyzou ; Panagoutsos, Stylianos ; Mallamaci, Francesca ; Postorino, Adele ; Cambareri, Francesco ; Matceac, Irina ; Nistor, Ionut ; Groeneveld, J. H.M ; Jousma, Jolanda ; van Buren, Marjolijn ; Diekmann, Fritz ; Oppenheimer, Federico ; Blasco, Miquel ; Pereira, Tiago Assis ; Santos, Augusto Cesar S ; Arias-Cabrales, Carlos ; Crespo, Marta ; Llinàs-Mallol, Laura ; Buxeda, Anna ; Tàrrega, Carla Burballa ; Redondo-Pachon, Dolores ; Jimenez, Maria Dolores Arenas ; Mendoza-Valderrey, Alberto ; Martins, Ana Cristina ; Mateus, Catarina ; Alvila, Goncalo ; Laranjinha, Ivo ; Hofstra, Julia M ; Siezenga, Machiel A ; Franco, Antonio ; Arroyo, David ; Castellano, Sandra ; Rodríguez-Ferrero, Maria Luisa ; Manzanos, Sagrario Balda ; Barrios, R. Haridian Sosa ; Lemahieu, Wim ; Bartelet, Karlijn ; Dirim, Ahmet Burak ; Demir, Erol ; Sever, Mehmet Sukru ; Turkmen, Aydin ; Şafak, Seda ; Hollander, Daan A. M. J ; Büttner, Stefan ; de Vries, Aiko P. J ; Meziyerh, Soufian ; van der Helm, Danny ; Mallat, Marko ; Bouwsma, Hanneke ; Sridharan, Sivakumar ; Petrulienė, Kristina ; Maloney, Sharon-Rose ; Verberk, Iris ; van der Sande, Frank M ; Christiaans, Maarten H. L ; Hemmelder, Marc H ; MohanKumar, N ; Di Luca, Marina ; Tuğlular, Serhan Z ; Kramer, Andrea B ; Beerenhout, Charles ; Luik, Peter T ; Kerschbaum, Julia ; Tiefenthaler, Martin ; Watschinger, Bruno ; Stepanov, Vadim A ; Zulkarnaev, Alexey B ; Turkmen, Kultigin ; Gandolfini, Ilaria ; Maggiore, Umberto ; Fliedner, Anselm ; Åsberg, Anders ; Mjoen, Geir ; Miyasato, Hitoshi ; de Fijter, Carola W. H ; Mongera, Nicola ; Pini, Stefano ; de Biase, Consuelo ; Kerckhoffs, Angele ; van de Logt, Anne Els ; Maas, Rutger ; Hilbrands, Luuk B ; Lebedeva, Olga ; Lopez, Veronica ; Reichert, Louis J. M ; Verhave, Jacobien ; Titov, Denis ; Parshina, Ekaterina V ; Zanoli, Luca ; Marcantoni, Carmelita ; van Kempen, Gijs ; van Gils-Verrij, Liesbeth E. A ; Harty, John C ; Meurs, Marleen ; Myslak, Marek ; Battaglia, Yuri ; Lentini, Paolo ; den Deurwaarder, Edwin ; Stendahl, Maria ; Rahimzadeh, Hormat ; Rychlik, Ivan ; Cabezas-Reina, Carlos J ; Roca, Ana Maria ; Nauta, Ferdau ; Sahin, İdris ; Goffin, Eric ; Kanaan, Nada ; Labriola, Laura ; Devresse, Arnaud ; Diaz-Mareque, Anabel ; Coca, Armando ; de Arriba, Gabriel ; Meijers, Björn K. I ; Naesens, Maarten ; Kuypers, Dirk ; Desschans, Bruno ; Tonnerlier, Annelies ; Wissing, Karl M ; Dedinska, Ivana ; Pessolano, Giuseppina ; Malik, Shafi ; Dounousi, Evangelia ; Papachristou, Evangelos ; Berger, Stefan P ; Sanders, Jan Stephan F ; Franssen, Casper F. M ; Özyilmaz, Akin ; Ponikvar, Jadranka Buturović ; Pernat, Andreja Marn ; Kovac, Damjan ; Arnol, Miha ; Ekart, Robert ; Abrahams, Alferso C ; Molenaar, Femke M ; van Zuilen, Arjan D ; Meijvis, Sabine C. A ; Dolmans, Helma ; Tantisattamo, Ekamol ; Esposito, Pasquale ; Krzesinski, Jean-Marie ; Barahira, Jean Damacène ; Gallieni, Maurizio ; Martin-Moreno, Paloma Leticia ; Guglielmetti, Gabriele ; Guzzo, Gabriella ; Toapanta, Nestor ; Soler, Maria Jose ; Luik, Antinus J ; van Kuijk, Willi H. M ; Stikkelbroeck, Lonneke W. H ; Hermans, Marc M. H ; Rimševičius, Laurynas ; Righetti, Marco ; Islam, Mahmud
DOI	10.1038/s41598-022-22657-4
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Is Part of	Scientific reports.. Berlin : Nature Portfolio. 2022, vol. 12, iss. 1, art. no. 17978, p. [1-13].. eISSN 2045-2322
Abstract [eng]	In the general population with COVID-19, the male sex is an established risk factor for mortality, in part due to a more robust immune response to COVID-19 in women. Because patients on kidney function replacement therapy (KFRT) have an impaired immune response, especially kidney transplant recipients due to their use of immunosuppressants, we examined whether the male sex is still a risk factor for mortality among patients on KFRT with COVID-19. From the European Renal Association COVID-19 Database (ERACODA), we examined patients on KFRT with COVID-19 who presented between February 1st, 2020, and April 30th, 2021. 1204 kidney transplant recipients (male 62.0%, mean age 56.4 years) and 3206 dialysis patients (male 61.8%, mean age 67.7 years) were examined. Three-month mortality in kidney transplant recipients was 16.9% in males and 18.6% in females (p = 0.31) and in dialysis patients 27.1% in males and 21.9% in females (p = 0.001). The adjusted HR for the risk of 3-month mortality in males (vs females) was 0.89 (95% CI 65, 1.23, p = 0.49) in kidney transplant recipients and 1.33 (95% CI 1.13, 1.56, p = 0.001) in dialysis patients (pinteraction = 0.02). In a fully adjusted model, the aHR for the risk of 3-month mortality in kidney transplant recipients (vs. dialysis patients) was 1.39 (95% CI 1.02, 1.89, p = 0.04) in males and 2.04 (95% CI 1.40, 2.97, p < 0.001) in females (pinteraction = 0.02). In patients on KFRT with COVID-19, the male sex is not a risk factor for mortality among kidney transplant recipients but remains a risk factor among dialysis patients. The use of immunosuppressants in kidney transplant recipients, among other factors, may have narrowed the difference in the immune response to COVID-19 between men and women, and therefore reduced the sex difference in COVID-19 mortality risk.
Published	Berlin : Nature Portfolio
Type	Journal article
Language	English
Publication date	2022
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„Sex differences in COVID-19 mortality risk in patients on kidney function replacement therapy /“