| Title |
Core concepts in pharmacoepidemiology: measures of drug utilization based on individual-level drug dispensing data / |
| Authors |
Rasmussen, Lotte ; Wettermark, Bjorn Gunnar Erik Evert ; Steinke, Douglas ; Pottegård, Anton |
| DOI |
10.1002/pds.5490 |
| Full Text |
|
| Is Part of |
Pharmacoepidemiology and drug safety.. Hoboken : Willey. 2022, vol. 31, no. 10, p. 1015-1026.. ISSN 1053-8569. eISSN 1099-1557 |
| Keywords [eng] |
databases ; drug utilization ; incidence ; medication adherence ; pharmacoepidemiology ; prescribing patterns ; prevalence |
| Abstract [eng] |
Background: Drug utilization studies are essential to facilitate rational drug use in the society. Aim: In this review, we provide an overview of drug utilization measures that can be used with individual-level drug dispensing data, referencing additional reading on the individual analysis. This is intended to serve as a primer for those new to drug utilization research and a shortlist from which researchers can identify useful analytical approaches when designing their drug utilization study. Results and Discussion: We provide an overview of: (1) basic measures of drug utilization which are used to describe changes in drug use over time or compare drug use in different populations; (2) treatment adherence measures with specific focus on persistence and implementation; (3) how to measure drug combinations which is useful when assessing drug–drug interactions, concomitant treatment, and polypharmacy; (4) prescribing quality indicators and measures to assess variations in drug use which are useful tools to assess appropriate use of drugs; (5) proxies of prescription drug misuse and skewness in drug use; and (6) considerations when describing the characteristics of drug users or prescribers. |
| Published |
Hoboken : Willey |
| Type |
Journal article |
| Language |
English |
| Publication date |
2022 |
| CC license |
|
