| Title |
Prognostic value of CD8+ lymphocytes in hepatocellular carcinoma and perineoplastic parenchyma assessed by interface density profiles in liver resection samples / |
| Authors |
Stulpinas, Rokas ; Žilėnaitė-Petrulaitienė, Dovilė ; Rasmusson, Allan ; Gulla, Aistė ; Grigonytė, Agnė ; Strupas, Kęstutis ; Laurinavičius, Arvydas |
| DOI |
10.3390/cancers15020366 |
| Full Text |
|
| Is Part of |
Cancers.. Basel : MDPI. 2023, vol. 15, no. 2, art. no. 366, p. [1-18].. eISSN 2072-6694 |
| Keywords [eng] |
CD8 ; hepatocellular carcinoma ; immune response ; tumor-infiltrating lymphocytes ; liver-infiltrating lymphocytes ; digital image analysis ; immunohistochemistry ; computational pathology |
| Abstract [eng] |
In this study, we present the overall survival and recurrence-free survival models based on CD8 profiles in hepatocellular carcinoma (HCC) and peritumoral liver tissue, including other clinical and pathological variables. We extracted CD8 distribution profiles from the digitized immunohistochemistry slides containing the HCC-stroma interface and the perineoplastic liver parenchyma-stroma interface using the computational method of interface zone immunogradient. The prognostic value of the CD8+ cell spatial distribution indicators from both interfaces as well as clinical, laboratory, and pathology data was assessed. A three-tier prognostic scoring system is proposed to predict overall survival in patients with HCC. |
| Published |
Basel : MDPI |
| Type |
Journal article |
| Language |
English |
| Publication date |
2023 |
| CC license |
|
