Title Papillary Thyroid Carcinoma Tissue miR-146b, -21, -221, -222, -181b Expression in Relation with Clinicopathological Features /
Authors Kondrotienė, Aistė ; Daukša, Albertas ; Pamedytytė, Daina ; Kazokaitė, Mintautė ; Žvirblienė, Aurelija ; Daukšienė, Dalia ; Simanavičienė, Vaida ; Klimaitė, Raimonda ; Golubickaitė, Ieva ; Stakaitis, Rytis ; Šarauskas, Valdas ; Verkauskienė, Rasa ; Žilaitienė, Birutė
DOI 10.3390/diagnostics11030418
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Is Part of Diagnostics.. Basel : MDPI. 2021, vol. 11, iss. 3, art. no. 418, p. [1-21].. eISSN 2075-4418
Keywords [eng] papillary thyroid carcinoma ; miR-146 ; miR-21 ; miR-221 ; miR-222 ; miR-181b ; clinicopathologic features ; overall survival
Abstract [eng] We analyzed miR-146b, miR-21, miR-221, miR-21, and miR-181b in formalin fixed paraffin-embedded papillary thyroid carcinoma (PTC) tissue samples of 312 individuals and evaluated their expression relationship with clinicopathological parameters. A higher expression of miR-21 was related to unifocal lesions (p < 0.011) and autoimmune thyroiditis (0.007). miR-221, miR-222 expression was higher in the PTC tissue samples with extrathyroidal extension (p = 0.049, 0.003, respectively). In a group of PTC patients with pT1a and pT1b sized tumors, the expression of miR-146b, miR-21, miR-221, and miR-222 in PTC tissue samples was lower than in patients with pT2, pT3, and pT4 (p = 0.032; 0.0044; 0.003; 0.001; 0.001, respectively). Patients with lymph node metastases had higher expression of miR-21, -221, -222, and -181b (p < 0.05). A high expression of miR-146b, miR-21, miR-221 panel was associated with decreased overall survival (OS) (Log rank p = 0.019). Univariate analysis revealed that presence of metastatic lymph nodes and high expression of miR-146b, miR-21, and miR-221 panels were associated with increased hazard of shorter OS. After multivariate analysis, only sex (male) and age (≥55 years) emerged as independent prognostic factors associated with shorter OS (HR 0.28 (95% CI 0.09–0.86) and HR 0.05 (95% CI 0.01–0.22), respectively). In conclusion, 5 analyzed miRs expression have significant relations to clinicopathologic parameters so further investigations of these molecules are expedient while searching for prognostic PTC biomarkers.
Published Basel : MDPI
Type Journal article
Language English
Publication date 2021
CC license CC license description