| Abstract [eng] |
Liver fibrosis is a multi-factor process in the course of which, due to the long-term impact of the harmful factors denoted by various etiologies when the molecular and cellular response has already been triggered, tissue fibrosis is formed. Liver fibrosis and liver cirrhosis (as the final stage of liver fibrosis) determine the deterioration of the liver function, portal hypertension as well as many serious and even life-threatening complications, such as varicose bleeding, ascites, renal insufficiency, hepatic encephalopathy, spontaneous bacterial peritonitis and hepatic cell carcinoma (HCC). When a chronic liver disease is diagnosed, the identification of the degree (stage) of liver fibrosis is essential before the initiation of the treatment, and it is also fundamental for the assessment of the risks stemming from potential complications. There are multiple ways to establish the degree of liver fibrosis but only ultrasound and magnetic resonance elastography are included in to clinical guidelines while the role of other quantitative imaging modalities remains not defined. In addition, the staging of chronic liver diseases relies on clinical evaluation, laboratory tests and quantitative imaging as a complex. Aim of the thesis - The aim of the thesis is to assess and compare the diagnostic values of liver 2D-SWE elastography and liver dynamic scintigraphy with 99mTc-mebrofenin for the diagnosis and research of liver fibrosis. Objectives of the thesis: 1. To establish the precision of the 2D-SWE (2D shear wave elastography) test when assessing the degree of liver fibrosis for the evaluation of the values of the histological test of a fragment of liver tissue obtained by liver needle biopsy. 2. To establish the precision of the liver dynamic single-photon emission computed tomography with 99mTc-mebrofenin when assessing the degree of liver fibrosis in comparison with the values of the histological test of a fragment of liver tissue obtained by liver needle biopsy. 3. To compare the values of the ultrasound test 2D-SWE versus the value of 99mTc-mebrofenin for the detection of the degree of damage inflicted by diffuse liver disease (liver fibrosis) for the same set of patients by referring to the histological test of a tissue fragment obtained by liver biopsy and using it as the standard. 4. To establish the combined value of non-invasive radiological tests when determining the degree of liver fibrosis and to determine the relationship between the extent of damage with the results of the histological test. |
