| Title |
Ovarian Leydig cell tumor and ovarian hyperthecosis in a postmenopausal woman: a case report and literature review |
| Authors |
Bužinskienė, Diana ; Marčiukaitytė, Rūta ; Šidlovska, Evelina ; Rudaitis, Vilius |
| DOI |
10.3390/medicina59061097 |
| Full Text |
|
| Is Part of |
Medicina.. Basel : MDPI. 2023, vol. 59, iss. 6, art. no. 1097, p. [1-7].. ISSN 1010-660X. eISSN 1648-9144 |
| Keywords [eng] |
ovarian Leydig cell tumor ; ovarian hyperthecosis ; hyperandrogenism ; postmenopausal women ; salpingo-oophorectomy |
| Abstract [eng] |
Ovarian Leydig cell tumor is a rare type of ovarian steroid cell neoplasms, presenting in only 0.1% of all ovarian tumor cases, and is generally androgen-secreting and unilateral. Although they are often malignant non-spreading tumors, which have excellent prognosis, benign ovarian Leydig cell tumors with low-risk malignancy can be also detected. Ovarian hyperthecosis is a rare non-neoplastic disorder, in most cases bilateral. Ovarian tumors and ovarian hyperthecosis are one of the main causes of hyperandrogenism in postmenopausal women, a condition strongly associated with both hormonal and metabolic changes. Here, we report a 65-year-old patient with complaints of excessive body hairiness and alopecia. The laboratory investigation showed increased levels of serum testosterone and dehydroepiandrosterone sulfate (DHEA-S). Imaging, including transvaginal ultrasound and pelvic MRI revealed the presence of two masses in the ovaries. The patient underwent a laparoscopic bilateral salpingo-oophorectomy due to the ovarian tumors unknown etiology, and histopathological examination revealed a unilateral benign left ovarian Leydig cell tumor with bilateral ovarian stromal hyperplasia and ovarian hyperthecosis. Making differential diagnosis between ovarian tumors and ovarian hyperthecosis is difficult. Bilateral salpingo-oophorectomy is the treatment of choice in postmenopausal women with benign Leydig cell ovarian tumor, as well as ovarian hyperthecosis, as it offers both a cure and diagnostic confirmation. |
| Published |
Basel : MDPI |
| Type |
Journal article |
| Language |
English |
| Publication date |
2023 |
| CC license |
|
