| Abstract [eng] |
The incidence of oncological diseases in Lithuania and the world is increasing every year, but the mortality rate is decreasing at a similar rate thanks to the latest diagnostic and treatment tools. To find ways to improve bioimaging, multimodal materials are being developed. In the research we investigate the optimal concentration of Eu3+ resulting in more intensive emission of the samples and Gd3+ ions as well as attempt to stabilize the monoclinic monazite type structure by means of La3+ doping and analyze their effects on crystal structure, luminescence properties, and cytotoxicity. The aim is to develop an anhydrous of lanthanide phosphate with magnetic properties that can be used for multimodal imaging. Various characterization techniques, such as X-ray diffraction, spectroscopy, and magnetic measurements, have been employed in this research. We have analyzed the effect of particle size, length-to-width ratio, shape, and crystalline structure on the luminescence properties of the nanoparticles. We have explored controlling these particle characteristics to enhance the performance of the nanoparticles for bioimaging applications. The cytotoxicity of the Eu-doped GdPO4 nanoparticles has been evaluated to ensure their biocompatibility and non-toxicity. This analysis is crucial for determining the suitability of the nanoparticles for biomedical applications. |
