| Title |
Computational Modelling of Complex Biocatalytic Processes in Biosensors / |
| Translation of Title |
Kompiuterinis sudėtingų biokatalizės procesų biojutikliuose modeliavimas. |
| Authors |
Šimelevičius, Dainius |
| Full Text |
|
| Pages |
35 |
| Keywords [eng] |
modelling ; reaction-diffusion ; biosensor ; substrate and product inhibition ; substrate synergy |
| Abstract [eng] |
A biosensor is a device, used for the measurement of a concentration of an analyte. Biosensors are known to be cheap and reliable devices, however their development and calibration requires a lot of resources. In order to reduce the number of required physical experiments, mathematical modelling should be used. With the help of mathematical modelling it is possible to predict properties of biosensors prior to conducting physical experiments in a laboratory. The models of a biosensor with substrate and product inhibition as well as of a biosensor with synergistic substrates were defined in the dissertation. The software which automates the creation of biosensor models was developed. This software was used to investigate properties and behaviour of biosensors. Computational modelling showed that an amperometric biosensor with substrate inhibition can measure substrate concentration at a wider concentration range than one without substrate inhibition if other biosensor parameters are equal. |
| Type |
Summaries of doctoral thesis |
| Language |
English |
| Publication date |
2013 |
