Long-term outcomes of the global tuberculosis and COVID-19 co-infection cohort /

Nicolas Casco; Alberto Levi Jorge; Domingo Juan Palmero; Jan-Willem Alffenaar; Greg J Fox; Wafaa Ezz; Jin-Gun Cho; Justin Denholm; Alena Skrahina; Varvara Solodovnikova; Marcos Abdo Arbex; Tatiana Alves; Marcelo Fouad Rabahi; Giovana Rodrigues Pereira; Roberta Sales; Denise Rossato Silva; Muntasir M Saffie; Nadia Escobar Salinas; Ruth Caamaño Miranda; Catalina Cisterna; Clorinda Concha; Israel Fernandez; Claudia Villalón; Carolina Guajardo Vera; Patricia Gallegos Tapia; Viviana Cancino; Monica Carbonell; Arturo Cruz; Eduardo Muñoz; Camila Muñoz; Indira Navarro; Rolando Pizarro; Gloria Pereira Cristina Sánchez; Maria Soledad Vergara Riquelme; Evelyn Vilca; Aline Soto; Ximena Flores; Ana Garavagno; Martina Hartwig Bahamondes; Luis Moyano Merino; Ana María Pradenas; Macarena Espinoza Revillot; Patricia Rodriguez; Angeles Serrano Salinas; Carolina Taiba; Joaquín Farías Valdés; Jorge Navarro Subiabre; Carlos Ortega; Sofia Palma; Patricia Perez Castillo; Mónica Pinto; Francisco Rivas Bidegain; Margarita Venegas; Edith Yucra; Yang Li; Andres Cruz; Beatriz Guelvez; Regina Victoria Plaza; Kelly Yoana Tello Hoyos; José Cardoso-Landivar; Martin Van Den Boom; Claire Andréjak; François-Xavier Blanc; Samir Dourmane; Antoine Froissart; Armine Izadifar; Frédéric Rivière; Frédéric Schlemmer; Katerina Manika; Boubacar Djelo Diallo; Souleymane Hassane-Harouna; Norma Artiles; Licenciada Andrea Mejia; Nitesh Gupta; Pranav Ish; Gyanshankar Mishra; Jigneshkumar M Patel; Rupak Singla; Zarir F Udwadia; Francesca Alladio; Fabio Angeli; Andrea Calcagno; Rosella Centis; Luigi Ruffo Codecasa; Angelo De Lauretis; Susanna M R Esposito; Beatrice Formenti; Alberto Gaviraghi; Vania Giacomet; Delia Goletti; Gina Gualano; Alberto Matteelli; Giovanni Battista Migliori; Ilaria Motta; Fabrizio Palmieri; Emanuele Pontali; Tullio Prestileo; Niccolò Riccardi; Laura Saderi; Matteo Saporiti; Giovanni Sotgiu; Antonio Spanevello; Claudia Stochino; Marina Tadolini; Alessandro Torre; Simone Villa; Dina Visca; Xhevat Kurhasani; Mohammed Furjani; Najia Rasheed; Edvardas Danila; Saulius Diktanas; Ruy López Ridaura; Fátima Leticia Luna López; Marcela Muñoz Torrico; Adrian Rendon; Onno W Akkerman; Onyeaghala Chizaram; Seif Al-Abri; Fatma Alyaquobi; Khalsa Althohli; Sarita Aguirre; Rosarito Coronel Teixeira; Viviana De Egea; Sandra Irala; Angélica Medina; Guillermo Sequera; Natalia Sosa; Fátima Vázquez; Félix K Llanos-Tejada; Selene Manga; Renzo Villanueva-Villegas; David Araujo; Raquel DuarteTânia Sales Marques; Adriana Socaci; Olga Barkanova; Maria Bogorodskaya; Sergey Borisov; Andrei Mariandyshev; Anna Kaluzhenina; Tatjana Adzic Vukicevic; Maja Stosic; Darius Beh; Deborah Ng; Catherine W M Ong; Ivan Solovic; Keertan Dheda; Phindile Gina; José A Caminero; Maria Luiza De Souza Galvão; Angel Dominguez-Castellano; José-María García-García; Israel Molina Pinargote; Sarai Quirós Fernandez; Adrián Sánchez-Montalvá; Eva Tabernero Huguet; Miguel Zabaleta Murguiondo; Pierre-Alexandre Bart; Jesica Mazza-Stalder; Lia D'Ambrosio; Phalin Kamolwat; Freya Bakko; James Barnacle; Sophie Bird; Annabel Brown; Shruthi Chandran; Kieran Killington; Kathy Man; Padmasayee Papineni; Flora Ritchie; Simon Tiberi; Natasa Utjesanovic; Dominik Zenner; Jasie L Hearn; Scott Heysell; Laura Young

doi:10.1183/13993003.00925-2023

Title	Long-term outcomes of the global tuberculosis and COVID-19 co-infection cohort /
Authors	Casco, Nicolas ; Jorge, Alberto Levi ; Palmero, Domingo Juan ; Alffenaar, Jan-Willem ; Fox, Greg J ; Ezz, Wafaa ; Cho, Jin-Gun ; Denholm, Justin ; Skrahina, Alena ; Solodovnikova, Varvara ; Arbex, Marcos Abdo ; Alves, Tatiana ; Rabahi, Marcelo Fouad ; Pereira, Giovana Rodrigues ; Sales, Roberta ; Silva, Denise Rossato ; Saffie, Muntasir M ; Salinas, Nadia Escobar ; Miranda, Ruth Caamaño ; Cisterna, Catalina ; Concha, Clorinda ; Fernandez, Israel ; Villalón, Claudia ; Vera, Carolina Guajardo ; Tapia, Patricia Gallegos ; Cancino, Viviana ; Carbonell, Monica ; Cruz, Arturo ; Muñoz, Eduardo ; Muñoz, Camila ; Navarro, Indira ; Pizarro, Rolando ; Cristina Sánchez, Gloria Pereira ; Vergara Riquelme, Maria Soledad ; Vilca, Evelyn ; Soto, Aline ; Flores, Ximena ; Garavagno, Ana ; Bahamondes, Martina Hartwig ; Merino, Luis Moyano ; Pradenas, Ana María ; Revillot, Macarena Espinoza ; Rodriguez, Patricia ; Salinas, Angeles Serrano ; Taiba, Carolina ; Valdés, Joaquín Farías ; Subiabre, Jorge Navarro ; Ortega, Carlos ; Palma, Sofia ; Castillo, Patricia Perez ; Pinto, Mónica ; Bidegain, Francisco Rivas ; Venegas, Margarita ; Yucra, Edith ; Li, Yang ; Cruz, Andres ; Guelvez, Beatriz ; Victoria Plaza, Regina ; Tello Hoyos, Kelly Yoana ; Cardoso-Landivar, José ; Van Den Boom, Martin ; Andréjak, Claire ; Blanc, François-Xavier ; Dourmane, Samir ; Froissart, Antoine ; Izadifar, Armine ; Rivière, Frédéric ; Schlemmer, Frédéric ; Manika, Katerina ; Diallo, Boubacar Djelo ; Hassane-Harouna, Souleymane ; Artiles, Norma ; Mejia, Licenciada Andrea ; Gupta, Nitesh ; Ish, Pranav ; Mishra, Gyanshankar ; Patel, Jigneshkumar M ; Singla, Rupak ; Udwadia, Zarir F ; Alladio, Francesca ; Angeli, Fabio ; Calcagno, Andrea ; Centis, Rosella ; Codecasa, Luigi Ruffo ; De Lauretis, Angelo ; Esposito, Susanna M R ; Formenti, Beatrice ; Gaviraghi, Alberto ; Giacomet, Vania ; Goletti, Delia ; Gualano, Gina ; Matteelli, Alberto ; Migliori, Giovanni Battista ; Motta, Ilaria ; Palmieri, Fabrizio ; Pontali, Emanuele ; Prestileo, Tullio ; Riccardi, Niccolò ; Saderi, Laura ; Saporiti, Matteo ; Sotgiu, Giovanni ; Spanevello, Antonio ; Stochino, Claudia ; Tadolini, Marina ; Torre, Alessandro ; Villa, Simone ; Visca, Dina ; Kurhasani, Xhevat ; Furjani, Mohammed ; Rasheed, Najia ; Danila, Edvardas ; Diktanas, Saulius ; Ridaura, Ruy López ; Luna López, Fátima Leticia ; Torrico, Marcela Muñoz ; Rendon, Adrian ; Akkerman, Onno W ; Chizaram, Onyeaghala ; Al-Abri, Seif ; Alyaquobi, Fatma ; Althohli, Khalsa ; Aguirre, Sarita ; Teixeira, Rosarito Coronel ; De Egea, Viviana ; Irala, Sandra ; Medina, Angélica ; Sequera, Guillermo ; Sosa, Natalia ; Vázquez, Fátima ; Llanos-Tejada, Félix K ; Manga, Selene ; Villanueva-Villegas, Renzo ; Araujo, David ; Sales Marques, Raquel DuarteTânia ; Socaci, Adriana ; Barkanova, Olga ; Bogorodskaya, Maria ; Borisov, Sergey ; Mariandyshev, Andrei ; Kaluzhenina, Anna ; Vukicevic, Tatjana Adzic ; Stosic, Maja ; Beh, Darius ; Ng, Deborah ; Ong, Catherine W M ; Solovic, Ivan ; Dheda, Keertan ; Gina, Phindile ; Caminero, José A ; De Souza Galvão, Maria Luiza ; Dominguez-Castellano, Angel ; García-García, José-María ; Pinargote, Israel Molina ; Fernandez, Sarai Quirós ; Sánchez-Montalvá, Adrián ; Huguet, Eva Tabernero ; Murguiondo, Miguel Zabaleta ; Bart, Pierre-Alexandre ; Mazza-Stalder, Jesica ; D'Ambrosio, Lia ; Kamolwat, Phalin ; Bakko, Freya ; Barnacle, James ; Bird, Sophie ; Brown, Annabel ; Chandran, Shruthi ; Killington, Kieran ; Man, Kathy ; Papineni, Padmasayee ; Ritchie, Flora ; Tiberi, Simon ; Utjesanovic, Natasa ; Zenner, Dominik ; Hearn, Jasie L ; Heysell, Scott ; Young, Laura
DOI	10.1183/13993003.00925-2023
Full Text
Is Part of	European respiratory journal.. Sheffield : European Respiratory Society (ERS). 2023, vol. 62, iss. 5, art. no. 2300925, p. [1-12].. ISSN 0903-1936. eISSN 1399-3003
Abstract [eng]	BACKGROUND: Longitudinal cohort data of patients with tuberculosis (TB) and coronavirus disease 2019 (COVID-19) are lacking. In our global study, we describe long-term outcomes of patients affected by TB and COVID-19. METHODS: We collected data from 174 centres in 31 countries on all patients affected by COVID-19 and TB between 1 March 2020 and 30 September 2022. Patients were followed-up until cure, death or end of cohort time. All patients had TB and COVID-19; for analysis purposes, deaths were attributed to TB, COVID-19 or both. Survival analysis was performed using Cox proportional risk-regression models, and the log-rank test was used to compare survival and mortality attributed to TB, COVID-19 or both. RESULTS: Overall, 788 patients with COVID-19 and TB (active or sequelae) were recruited from 31 countries, and 10.8% (n=85) died during the observation period. Survival was significantly lower among patients whose death was attributed to TB and COVID-19 versus those dying because of either TB or COVID-19 alone (p<0.001). Significant adjusted risk factors for TB mortality were higher age (hazard ratio (HR) 1.05, 95% CI 1.03-1.07), HIV infection (HR 2.29, 95% CI 1.02-5.16) and invasive ventilation (HR 4.28, 95% CI 2.34-7.83). For COVID-19 mortality, the adjusted risks were higher age (HR 1.03, 95% CI 1.02-1.04), male sex (HR 2.21, 95% CI 1.24-3.91), oxygen requirement (HR 7.93, 95% CI 3.44-18.26) and invasive ventilation (HR 2.19, 95% CI 1.36-3.53). CONCLUSIONS: In our global cohort, death was the outcome in >10% of patients with TB and COVID-19. A range of demographic and clinical predictors are associated with adverse outcomes.
Published	Sheffield : European Respiratory Society (ERS)
Type	Journal article
Language	English
Publication date	2023
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„Long-term outcomes of the global tuberculosis and COVID-19 co-infection cohort /“