| Title |
Arterinio kraujospūdžio korekcijos, pritaikant giliosios galvos smegenų stimuliacijos metodą gyvūnų modelyje, tyrimas / |
| Translation of Title |
Arterial blood pressure correction applying deep brain stimulation method in an animal model. |
| Authors |
Chomanskis, Žilvinas |
| DOI |
10.15388/vu.thesis.570 |
| Full Text |
|
| Pages |
112 |
| Keywords [eng] |
caudal ventrolateral medulla ; arterial blood pressure ; deep brain stimulation ; arterial hypertension |
| Abstract [eng] |
This thesis explores the feasibility of using deep brain stimulation to regulate arterial blood pressure. To conduct the study, an in vivo model system was developed, wherein a laboratory rat was subjected to deep brain stimulation pulse generator along with an integrated invasive arterial blood pressure measurement and wireless data transmission system while moving freely. The literature review describes the main nuclei-targets that could be stimulated to produce a significant hypotensive effect. The study proposes that the caudal ventral lateral medulla could be an effective area for stimulation. The study demonstrated that the device is stable and allows for recording invasive blood pressure while simultaneously stimulating targets in the medulla oblongata in vivo. The pressure sensor's sensitivity and zero drift did not show significant changes during a long-term experiment in vivo, making it suitable for further experimentation. Implantation of electrodes into caudal ventrolateral medulla is a relatively safe intervention that does not cause significant neurological complications or excessive death of laboratory animals. Furthermore, stimulation of caudal ventrolateral medulla produces a hypotensive effect in a freely moving conscious rat. |
| Dissertation Institution |
Vilniaus universitetas. |
| Type |
Doctoral thesis |
| Language |
Lithuanian |
| Publication date |
2023 |
