Title A copper-containing analog of the biomineral whitlockite: dissolution-precipitation synthesis, structural and biological properties /
Authors Griesiūtė, Diana ; Kizalaitė, Agnė ; Dubnika, Arita ; Klimavičius, Vytautas ; Kalendra, Vidmantas ; Tyrpekl, Vaclav ; Cho, Sung Hun ; Goto, Tomoyo ; Sekino, Tohru ; Žarkov, Aleksej
DOI 10.1039/d3dt03756h
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Is Part of Dalton transactions.. Cambridge : Royal Society of Chemistry. 2024, vol. 53, iss. 4, p. 1722-1734.. ISSN 1477-9226. eISSN 1477-9234
Abstract [eng] In the present work, copper whitlockite (Cu-WH, Ca18Cu2(HPO4)2(PO4)12) was successfully synthesized and comprehensively characterized, founding the base knowledge for its future studies in medicine, particularly for bone regeneration. This material is a copper-containing analog of the well-known biomineral magnesium whitlockite (Mg-WH, Ca18Mg2(HPO4)2(PO4)12). The synthesis of powders was performed by a dissolution-precipitation method in an aqueous medium under hydrothermal conditions. Phase conversion from brushite (CaHPO4·2H2O) to Cu-WH took place in an acidic medium in the presence of Cu2+ ions. Optimization of the synthesis conditions in terms of medium pH, temperature, time, Ca/Cu molar ratio and concentration of starting materials was performed. The crystal structure of the synthesized products was confirmed by XRD, FTIR and Raman spectroscopy, 1H and 31P solid-state NMR, and EPR. Morphological features and elemental distribution of the synthesized powders were studied by means of SEM/EDX analysis. The ion release in SBF solution was estimated using ICP-OES. Cytotoxicity experiments were performed with MC3T3-E1 cells. The study on thermal stability revealed that the synthesized material is thermally unstable and gradually decomposes upon annealing to Cu-substituted β-Ca3(PO4)2 and Ca2P2O7.
Published Cambridge : Royal Society of Chemistry
Type Journal article
Language English
Publication date 2024
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