| Title |
Sonographic, demographic, and clinical characteristics of pre- and postmenopausal women with endometrial cancer; results from a post hoc analysis of the IETA4 (International Endometrial Tumor Analysis) multicenter cohort / |
| Authors |
Green, Rasmus W ; Fischerová, Daniela ; Testa, Antonia C ; Franchi, Dorella ; Frühauf, Filip ; Lindqvist, Pelle G ; di Legge, Alessia ; Cibula, David ; Fruscio, Robert ; Haak, Lucia A ; Opolskienė, Gina ; Vidal Urbinati, Ailyn M ; Timmerman, Dirk ; Bourne, Tom ; van den Bosch, Thierry ; Epstein, Elisabeth |
| DOI |
10.3390/diagnostics14010001 |
| Full Text |
|
| Is Part of |
Diagnostics.. Basel : Multidisciplinary Digital Publishing Institute (MDPI). 2024, vol. 14, iss. 1, art. no. 1, p. [1-13].. eISSN 2075-4418 |
| Keywords [eng] |
biometry ; endometrial neoplasms ; exploratory research ; lifestyle ; perimenopause ; postmenopause ; premenopause ; risk factors ; ultrasonography |
| Abstract [eng] |
In this study, we conducted a comparative analysis of demographic, histopathological, and sonographic characteristics between pre- and postmenopausal women diagnosed with endometrial cancer, while also examining sonographic and anthropometric features in ‘low’ and ‘intermediate/high-risk’ cases, stratified by menopausal status. Our analysis, based on data from the International Endometrial Tumor Analysis (IETA) 4 cohort comprising 1538 women (161 premenopausal, 1377 postmenopausal) with biopsy-confirmed endometrial cancer, revealed that premenopausal women, compared to their postmenopausal counterparts, exhibited lower parity (median 1, IQR 0–2 vs. 1, IQR 1–2, p = 0.001), a higher family history of colon cancer (16% vs. 7%, p = 0.001), and smaller waist circumferences (median 92 cm, IQR 82–108 cm vs. 98 cm, IQR 87–112 cm, p = 0.002). Premenopausal women more often had a regular endometrial–myometrial border (39% vs. 23%, p < 0.001), a visible endometrial midline (23% vs. 11%, p < 0.001), and undefined tumor (73% vs. 84%, p = 0.001). Notably, despite experiencing a longer duration of abnormal uterine bleeding (median 5 months, IQR 3–12 vs. 3 months, 2–6, p < 0.001), premenopausal women more often had ‘low’ risk disease (78% vs. 46%, p < 0.001). Among sonographic and anthropometric features, only an irregular endometrial–myometrial border was associated with ‘intermediate/high’ risk in premenopausal women. Conversely, in postmenopausal women, multiple features correlated with ‘intermediate/high’ risk disease. Our findings emphasize the importance of considering menopausal status when evaluating sonographic features in women with endometrial cancer. |
| Published |
Basel : Multidisciplinary Digital Publishing Institute (MDPI) |
| Type |
Journal article |
| Language |
English |
| Publication date |
2024 |
| CC license |
|
