| Title |
Cationized and poly(ethylene glycol) modified chitosan derivatives and nanoparticles / |
| Translation of Title |
Katijonizuoti ir polietilenglikoliu modifikuoti chitozano dariniai bei nanodalelės. |
| Authors |
Gruškienė, Rūta |
| Full Text |
|
| Pages |
28 |
| Keywords [eng] |
chitosan ; MPEG ; "click" ; cationization |
| Abstract [eng] |
The main aim of this work was to synthesize water-soluble chitosan – methoxy poly(ethylene glycol) (MPEG) graft copolymers and cationized chitosan derivatives of various structure and desirable graft density, and to study their properties. Novel chitosan-MPEG derivatives with different degree of substitution of chitosan were prepared for the first time by “click” chemistry. Several new schemes of the synthesis of chitosan-MPEG and additionally cationized chitosan derivatives were suggested based on protection of amino functionality by using chitosan-dodecyl sulphate complexes. Additional cationization of chitosan through its hydroxyl groups in alkaline medium enabled to prepare chitosan derivatives with very high charge density. A method of enzymatic hydrolysis of the cationized chitosans was proposed which allowed a tenfold decrease of the molecular weight of chitosan derivatives. Modification of chitosan by tartaric, citric or adipic acid yielded chitosan nanoparticles. Further modification of chitosan nanoparticles by dithiobenzendicarboxylate resulted in RAFT macroinitiators used as precursors of functionalized nanoparticles. |
| Type |
Summaries of doctoral thesis |
| Language |
English |
| Publication date |
2010 |
