| Title |
Localised electrochemical impedance spectroscopy of gold nanoparticles labelled antibodies probed by platinum microstructured ultramicroelectrode / |
| Authors |
Zinovičius, Antanas ; Morkvėnaitė-Vilkončienė, Inga ; Ramanavičius, Arūnas |
| DOI |
10.3390/ma17061339 |
| Full Text |
|
| Is Part of |
Materials: Special Issue: Advanced Microscopy Techniques in Materials Science: Properties and Applications.. Basel : MDPI. 2024, vol. 17, iss. 6, art. no. 1339, p. 1-11.. eISSN 1996-1944 |
| Keywords [eng] |
scanning electrochemical impedance microscopy ; SEIM ; ultramicroelectrode ; electrode modification ; electrochemical immunosensor ; transducer ; reusable transducer |
| Abstract [eng] |
This research is focused on enhancing the capabilities of scanning electrochemical impedance microscopy (SEIM) for detecting gold nanoparticle-labelled antibodies using electrochemically modified platinum ultramicroelectrode. The primary objective was to address the high resistance issue encountered in previous measurements with SEIM via the utilization of SEIM probes based on micro-electrodes modified by platinum microstructures, which improved the sensitivity and precision of the detection of targeted biomolecules. The modified probe resulted in a lowered charge transfer resistance by over ten times and a decrease in detection to around 100 fg/mL. We suggest potential applications in various biotechnological and biomedical fields, with future research expected to further refine this technique. |
| Published |
Basel : MDPI |
| Type |
Journal article |
| Language |
English |
| Publication date |
2024 |
| CC license |
|
