Title Kognityvinių funkcijų sutrikimai sergant Išsėtine skleroze, jų ryšys su demografiniais klinikiniais rodikliais ir pakitimais Magnetinio rezonanso tomografijos tyrime /
Translation of Title Cognitive dysfunction in Multiple sclerosis, its relationship with demographic and clinical factors and changes in Magnetic resonance imaging.
Authors Kizlaitienė, Rasa
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Pages 51
Keywords [eng] Multiple sclerosis ; cognitive dysfunction ; Magnetic resonance imaging
Abstract [eng] Multiple sclerosis (MS) is a chronic demyelinating inflammatory neurological disease in young adults. Cognitive dysfunction (CD) contributes significantly to patient’s disability status. Although almost all kind of CD can be observed in MS, the typical profile is the impairment of information processing speed, memory, attention and often executive skills. The aim of the study was to investigate the influence of different demographic and clinical markers of the disease and changes in MRI tomography on cognitive functions in MS patients. The study involved 120 patients with MS and 40 healthy controls. Neurological examination, complaints of memory and fatigue, objective depression, anxiety and objective fatigue were evaluated. Cognitive functions (CF) were tested using battery of 11 cognitive tests. Brain MRI was performed to evaluate focal demyelinised lesions and to calculate regional linear markers of brain atrophy. The impairment of CF was much more expressed in MS patients as compared to controls. CF were negatively affected by objective depression and disease course. Subjective memory complaints and subjective fatigue in MS patients did not correlate with CF however they did correlate with objective fatigue. Self reported memory impairment worsened with the progression of disease. CD and brain atrophy reflected by MRI linear parameters were more expressed in secondary progressive (SP) MS as compared to relapsing remitting (RR) MS. Number of demyelinated lesions were related to CF in RR MS. MRI linear measurements bicaudatus ratio and width of the third ventricle, also cognitive tests reflecting verbal learning and memory, speed of psychomotor reactions and attention were mostly suitable to differentiate RR and SP MS courses.
Type Summaries of doctoral thesis
Language Lithuanian
Publication date 2012