| Abstract [eng] |
SUMMARY The Origin and the Incidence of Antibodies against Rhesus Blood System Antigens This research work was carried out seeking to assess origin and incidence of antibodies against antigens of Rhesus Blood Type system as well as their distribution after hemotransfusions. Blood of 115 recipients was explored in patients treated at Vilnius University hospital „Santariškių klinikos”. The age of the persons under research varied between 18 and 82 years. Appearance and spread of antibodies against antigens of Rhesus Blood Type system was established using the direct and indirect Coombs test. We had explored the risk of alloimmunization of antibodies against antigens of Rhesus Blood Type system within the period of four years. The risk of alloimmunization of alloantibodies against antigens of Rhesus Blood Type system, which we found on the first time within the first year of research was 9.56 %. And in the end of research, the risk of alloimmunization of alloantibodies against antigens of Rhesus Blood Type system, which we found on the first time was 19.13 %. On the whole, within the first year of research, alloantibodies against antigens of Rhesus Blood Type system were identified in 92.17 % of the patients, and the autoantibodies against antigens of Rhesus Blood Type – in 7.83 % of the patients.Within the fourth year of research, in total 75.47 % of the patients were identified alloantibodies against antigens of Rhesus Blood Type system, and the autoantibodies against antigens of Rhesus Blood were not found in patients. Most frequently, alloantibodies of Rhesus Blood Type system were presented by the ones against D antigens (n = 24) and E antigens (n = 19); the most frequent combinations of antibodies of Rh Blood Type system were: anti – (D + C) (n = 3), anti – (E + Cw) (n = 4), anti – (E + c) (n = 3) and anti – (D + C + E) (n = 5). An archetypal dynamics of detection of alloantibodies against antigens of Rhesus Blood Type system were among patients ill with hematological diseases, cardiac and cardiovascular diseases, and with surgical diseases of the abdominal zone. |
