Title Human gut microbiome: Therapeutic opportunities for metabolic syndrome—Hype or hope? /
Authors Horvath, Angela ; Žukauskaitė, Kristina ; Hazia, Olha ; Balazs, Irina ; Stadlbauer, Vanessa
DOI 10.1002/edm2.436
Full Text Download
Is Part of Endocrinology, diabetes and metabolism.. Hoboken : John Wiley and Sons Inc. 2024, vol. 7, iss. 1, p. [1-32].. eISSN 2398-9238
Keywords [eng] diet ; faecal microbiota transplantation ; metabolic syndrome ; microbiome ; obesity ; prebiotic ; probiotic
Abstract [eng] Shifts in gut microbiome composition and metabolic disorders are associated with one another. Clinical studies and experimental data suggest a causal relationship, making the gut microbiome an attractive therapeutic goal. Diet, intake of probiotics or prebiotics and faecal microbiome transplantation (FMT) are methods to alter a person's microbiome composition. Although FMT may allow establishing a proof of concept to use microbiome modulation to treat metabolic disorders, studies show mixed results regarding the effects on metabolic parameters as well as on the composition of the microbiome. This review summarizes the current knowledge on diet, probiotics, prebiotics and FMT to treat metabolic diseases, focusing on studies that also report alterations in microbiome composition. Furthermore, clinical trial results on the effects of common drugs used to treat metabolic diseases are synopsized to highlight the bidirectional relationship between the microbiome and metabolic diseases. In conclusion, there is clear evidence that microbiome modulation has the potential to influence metabolic diseases; however, it is not possible to distinguish which intervention is the most successful. In addition, a clear commitment from all stakeholders is necessary to move forward in the direction of developing targeted interventions for microbiome modulation.
Published Hoboken : John Wiley and Sons Inc
Type Journal article
Language English
Publication date 2024
CC license CC license description