| Abstract [eng] |
Many of recently used chemotherapeutic agents have a quinoidal structure. It is supposed that the main mechanism of antitumour aziridinyl substituted benzoquinones is their two-electron reduction to alkylating products. However, other possible cytotoxicity mechanisms, e.g., oxidative stress, are studied insufficiently. The goal of our investigation was to analyse quinones influence to apoptosis in FLK (foetal lamb kidney fibroblasts) line, which posses increased prooxidant activities. The results show that quinones, which have aziridinyl substituents (RH1 and MeDZQ) are more cytotoxic than quinones without these substituents (daunorubicin and duroquinone). Cytotoxic effect of those quinones to cells is conditioned by combinative mechanism of oxidative stress, DT-diaforase and xantinoxidase action. It is supposed that aziridinyl substituted benzoquinones may be very perspective in antitumour treatment. |
