| Abstract [eng] |
Electroencephalography is one of the most important methods of examining patients with epilepsy. Quantitative electroencephalogram analysis, used to document the effects of specific drugs on the bioelectrical activity of the brain, is known as a pharmacological electroencephalogram. Considering the low cost of the standard electroencephalogram, wide availability and non-invasiveness of this method, the full potential of the pharmacological electroencephalogram in epileptic research, has not been fully exploited yet. The purpose of this literature review was to review pharmacological electroencephalography studies in humans taking antiseizure medication and to analyze their results. A systematic literature search in the PubMed, ScienceDirect and Google Scholar databases was used for the review. 167 articles matched the search criteria, of which 39 duplicate articles were found. Articles were reviewed and some of them were excluded, according to certain criteria described in the methodology section. After selection, 12 articles remained. These articles and bibliographic sources were reviewed, 24 articles were selected for inclusion in this literature review. The most used method for electroencephalogram interpretation was the analysis of the frequency characteristics, which considered the frequency and dose of drug administration. This method was often combined with quantitative evaluation methods, such as spectral analysis. Although drug effects on brain activity have been documented, few studies have been conducted to analyze and predict treatment response, detect neurotoxic effects, and assess the reversibility of antiseizure medication induced changes. A specific clinical case report is also provided. |
