| Abstract [eng] |
The prevalence of hypertensive disorders of pregnancy is 5-8% and it is increasing each year. Preeclampsia is one of the most common causes of maternal, fetal, neonatal mortality and leads to short-term and long-term complications. Diagnosing and predicting the outcomes of these disorders can be challenging despite clearly defined diagnostic criteria. The discovery of angiogenic factors’ role in preeclampsia has provided a basis for new studies. The goals of our study were to compare the risk factors of preeclampsia and cardiovascular diseases, the differences in angiogenic factors and ultrasound indices in different groups of hypertensive disorders of pregnancy. The study included 19 patients with preeclampsia, 9 with gestational hypertension. The most common risk factors for preeclampsia were nulliparity, first pregnancy, obesity. The cardiovascular risk factors were family history of cardiovascular diseases, obesity. A significantly higher concentration of soluble fms-like tyrosine kinase-1, lower concentration of placental growth factor, higher ratio of these markers were found in preeclampsia group compared to gestational hypertension and preeclampsia with fetal growth restriction compared to preeclampsia alone. Preeclampsia with fetal growth restriction had significantly higher uterine artery pulsatility index compared to preeclampsia alone, also preeclampsia group had a higher uterine artery pulsatility index compared to gestational hypertension. Early preeclampsia had higher uterine artery resistancy index and lower serum concentration of placental growth factor compared to late preeclampsia. Based on the higher uterine artery indices and angiogenic factors imbalances, placental dysfunction is most pronounced in the preeclampsia with fetal growth restriction, followed by preeclampsia and gestational hypertension. |
