| Abstract [eng] |
Objective: To decribe the most common skin allergic reactions to beta-lactams and to analyze their principal pathogenetic factors. Material and methods: A review of the literature was based on PRISMA methology and guidelines. The bibliographic database Pubmed was used for the search. Keywords used during the search: "drug hypersensitivity", "drug allergy", "beta lactam antibiotics", etc. Information used until July 2022. 613 articles with keywords were found in the search period. 45 articles are included in the analysis of literature sources. Conclusions: Drug hypersensitivity reactions account for about one-third of adverse drug reactions, with beta-lactam antibiotics accounting for the largest percentage. There are several mechanisms that explain how drugs induce an immune response. This paper describes the concepts of hapten and P – i. Drug-induced hypersensitivity reactions are clinically variable. The most common manifestation is the maculopapular eruption of skin, but other organs can also be affected. Rashes of drug reactions range from mild, transient local rashes to severe life-threatening conditions that occur rapidly and involve multiple organ systems. |
