| Abstract [eng] |
Every athlete is inevitably susceptible to injury. Football performance relies on optimal anaerobic and aerobic traits, as well as minimizing the risk of soft-tissue injuries. In recent years, studies of the genetic profile of athletic performance and trauma risk have become more relevant. The aim of this study was to analyse and evaluate the genetic profile of physical performance and risk of injury in professional Lithuanian football players. 10 genetic polymorphism variants associated with these traits were examined: MCT1 rs1049434, COL1A1 rs1800012 and rs1107946, COL3A1 rs1800255, COL12A1 rs970547, TFAM rs1937, ACE rs1799752, ACTN3 rs1815739, AMPD1 rs17602729, and PPARGC1A rs8192678. The objective was to investigate the potential associations between these polymorphisms and athlete status, field position, and past injuries. The study involved 150 male Lithuanian football players and 150 sedentary males. Genotypes were determined using polymerase chain reaction, restriction fragment length polymorphism and TaqMan techniques. Data analysis was executed using Excel 365 and R Commander v2.8-0. ACE ID genotype, COL1A1 rs1107946 CA genotype, and MCT1 T allele and TT genotype were associated with athlete status. Lower injury risk was associated with the ACTN3 C allele and CC genotype, COL1A1 rs1800012 C allele and CC genotype, COL3A1 GG genotype, and MCT1 T allele and TT genotype. No associations were found between COL12A1, TFAM, AMPD1, PPARGC1A, and either athlete status or injury risk. Lithuanian football players possess a moderately advantageous genetic profile of athletic performance and trauma risk. Calculated total trauma risk genotype score proved to be a valuable tool to assess possible injury risk in Lithuanian football players. |
