| Abstract [eng] |
Aim: To examine the associations between COVID-19 infection and kidney injury in the regional hospital. Methods: 601 patient’s data from Vilnius regional university hospital between 1 January 2020 and 31 March 2021 were collected for this cross-sectional study. Demographic data (gender, age), clinical outcomes, length of stay, diagnoses (chronic kidney disease, acute kidney injury), and laboratory tests (creatinine, urea, C-reactive protein, potassium concentrations) data were collected and analyzed statistically by R Commander program. The PubMed literature (using the keywords) was reviewed and compared with the results of this study. Results: Patients discharged from the hospital were younger (63,18±16,02) than those from the emergency room (75,35±12,41, p<0,001), transferred to another hospital (72,89±12,06, p=0,002), or who died (70,87±12,83, p<0,001). Subsequently, patients who died had lower creatinine levels on the first day than those who were (185,00 vs. 311,17 μmol/l, p<0,001) discharged, and their hospital stay was longer (Spearman's correlation coefficient=-0,304, p<0,001). Patients with chronic kidney disease had higher creatinine concentration than patients with acute kidney injury (365,72±311,93 vs. 137,58±93,75, p<0,001). In older patients, chronic kidney disease was more often complicated by acute kidney injury during COVID-19 infection (72,66±11,98 vs. 68,35±14,86, p=0,014). Patients with chronic kidney disease complicated by acute kidney injury died 3,66 (p<0,001) times more often than patients with uncomplicated chronic kidney disease. Patients who did not have chronic kidney disease, but who developed acute kidney injury during hospitalization, were 7,81 times (p<0,001) more likely to end in death than patients with uncomplicated chronic kidney disease and 7,79 times (p<0,001) more like to end in death than patients with neither chronic kidney disease nor acute kidney injury. Conclusions: In older patients, chronic kidney disease was more often complicated by acute kidney injury during COVID-19 infection. COVID-19 patients who developed acute kidney injury and whose chronic kidney disease was complicated by acute kidney injury, had a longer hospital stay and were more likely to die. |
