| Abstract [eng] |
Coronavirus disease 2019 (COVID-19) is a newly occurred infection in 2019, caused by a virus, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The cells of the human body infected with the COVID-19 virus eventually apoptose, which is why a cytokine storm develops. When this process is extremely intense, organ failure or even, in the case of a pregnant woman, termination of pregnancy may develop. Due to the pro- inflammatory immunological state and compromised respiratory function, the COVID-19 infection is most dangerous for pregnant women in the third trimester of pregnancy. Clinical symptoms of COVID-19 infection differ little between infected pregnant and non-pregnant individuals. The main predictors of a severe course of the COVID-19 disease are a decrease in the number of erythrocytes and lymphocytes and increased levels of alanine aminotransferase and C-reactive protein. Pregnant COVID-19 patients with co-morbidities, such as preeclampsia, gestational diabetes, hypertension, obesity, have a higher risk of more severe COVID-19 infection. Also giving birth prematurely, giving birth to stillbirths or newborns with lower gestation weight and newborns with respiratory failure. However, the possibility of vertical transmission of the virus to the newborn is still debatable due to the insufficient amount of data. It has been observed that pregnant women with COVID-19 more often give birth by caesarean section. There is no etiological drug for the treatment of COVID-19 infection, so the treatment remains only symptomatic for all people, including pregnant women. The only treatment approved and recommended by the World Health Organization for pregnant women with COVID-19 infection is dexamethasone. The medical community also emphasizes the importance of antithrombotic treatment. Adequate prevention is an equally important method of managing the infection with COVID-19. The most effective is vaccination, which is suitable not only for pregnant women, but also for the entire human population. |
