| Abstract [eng] |
Bisphosphonates (BPs) have revolutionized the treatment of osteotropic diseases, but their use can lead to a rare but serious side effect termed medication-related osteonecrosis of the jaw (MRONJ). MRONJ can cause exposed bone lesions, resulting in pain, functional impairment, and reduced quality of life. This thesis advocates that interdisciplinary collaboration between healthcare professionals is crucial for effective prevention and management. MRONJ is likely to be underdiagnosed due to the absence of a universal disease code and various study objectives. Careful consideration of risk factors and detection of early radiographic signs of disease development are crucial for better treatment strategies and patient outcomes. Intravenous BPs carry a higher MRONJ risk than oral bisphosphonates. While the treatment effectiveness of drug holidays is not supported by research, antibiotic treatment is widely accepted at all stages of the disease. Conservative surgical treatment is an option for MRONJ at all stages, with early surgical intervention potentially leading to better outcomes. A systematic literature review was conducted to identify articles on bisphosphonates in dental surgery and medication-related osteonecrosis of the jaw, with a standardized data extraction form and thematic analysis of selected 57 out of 2773 initially screened articles based on their titles and abstracts. The aim of this thesis is to explore the intricacies of the implications of BPs in dental surgery, specifically the challenges associated with MRONJ and opportunities for optimizing treatment management. In conclusion, customizing treatment plans to suit the specific circumstances of each patient is essential for maximizing the effectiveness of treatment and reducing the likelihood of complications. |
