| Keywords [eng] |
Keywords: ketogenic diet, CRLM treatment, gut microbiome and CRLM, BHB supplements, NAFLD and CRLM, gut microbiome and KD, NAFLD and KD, metachronous CRLM, and KD adverse effects. |
| Abstract [eng] |
This literature review explores the impact of the Ketogenic Diet nutritional strategy, on colorectal liver metastasis (CRLM) factors and CRLM itself. It compares the effects of high-fat ketogenic versus standard diets on non-alcoholic fatty liver disease (NAFLD) and gut microbiome. Despite progress in cancer diagnosis and treatment, colorectal cancer (CRC) mortality remains high, with liver metastasis being a leading cause of death. The ketogenic diet, traditionally used for pediatric epilepsy, has gained popularity for managing gastrointestinal inflammation, metabolic diseases, and potentially cancer treatment. Recent studies reveal ketone bodies' antitumorigenesis effects, though the full benefits of ketosis are uncharted. Interestingly, the literature suggests that some of the metabolic and anti-tumorigenic effects of the ketogenic diet are age and sex dependent, favoring middle-aged healthy males. However, implementing the ketogenic diet can be challenging, especially for vulnerable advanced cancer patients. Ketone body supplementation is being investigated as an alternative to a restrictive diet. However, there is a lack of experimental data on how to adapt the ketogenic diet to adults, and it is even harder to adapt it to advanced cancer patients. Furthermore, the popularity of the ketogenic diethas led to an abundance and skewed literature. To address these issues, we conducted a literature review using inclusion and exclusion criteria for the studies reviewed. Informed by the research presented in this study, a manuscript has been crafted and submitted to the "Visceral Medicine" journal. |
