Title Recommendations for the use of tranexamic acid and the risk in the management of acute bleeding during anesthesia /
Translation of Title Recommendations for the Use of Tranexamic Acid and the Risk in the Management of Acute Bleeding During Anesthesia.
Authors Fidelman, Dana
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Pages 22
Keywords [eng] tranexamic acid, antifibrinolytic, acute bleeding, hemorrhage, trauma, surgery, cardiac surgery, traumatic brain injury, orthopedic surgery, adverse effect, CRASH trial, postpartum hemorrhage, TICH2 trial, WOMEN trial.
Abstract [eng] This narrative review will focus mainly on the indications and recommendations for the use of tranexamic acid and its use in the management of acute bleeding without evaluating the risk in the management of acute bleeding. Excessive bleeding and blood loss are among the leading causes of mortality. In the management of acute bleeding, one drug seems to be widely used among anaesthesiologists and surgeons all around the world - tranexamic acid. Tranexamic acid belongs to the antifibrinolytic drug group, as it prevents the degradation and dissolution of fibrin clots and helps maintain homeostasis. However, tranexamic acid carries the risk of serious adverse effects. Over the past decade, tranexamic acid has been extensively studied in various major clinical trials that have demonstrated its important role, efficacy, and effectiveness in preventing excessive blood loss and reducing blood transfusion requirements in various settings such as trauma, surgeries, traumatic brain injuries, and postpartum hemorrhages among others, leading the world health organisation to include it in its essential drug list. Tranexamic acid was found to be most effective when used in proximity to the time of injury and within three hours from the initial injury time in trauma settings. The optimal dosage and route of administration differ between various settings, and more studies are needed in order to optimize its use in the future.
Dissertation Institution Vilniaus universitetas.
Type Master thesis
Language English
Publication date 2023