| Abstract [eng] |
The COVID-19 disease presents with a wide range of clinical symptoms, from asymptomatic or mild disease to severe illness with respiratory failure and multiple organ dysfunction. The pathophysiology of COVID-19 involves a complex interaction between viral factors and the host immune response, which can lead to systemic inflammation and damage to multiple organ damage. Several risk factors for severe disease have been identified, including advanced age, cardiovascular disease, obesity, diabetes and pregnancy. In addition, some population groups, such as ethnic minorities and those of lower socio-economic status, may be disproportionately affected. In severe cases of COVID-19, respiratory failure is a common complication and might require mechanical ventilation or extracorporeal membrane oxygenation (ECMO). Other complications can affect almost all systems of the human body and lead to multiple organ failure. Treatment options for COVID-19 have evolved during the pandemic. At the beginning of the pandemic, supportive care was the main treatment option. However, several antiviral and immunomodulatory therapies have been developed and used in clinical practice. Two clinical cases of patients with COVID-19 will be used to illustrate the topic, focusing on the course of the disease and the treatment of symptoms. These cases can be considered as classic examples of what a SARS-CoV-2 infection looks like in the Omicron era of COVID-19. |
