Title Management of anaphylaxis in emergency department /
Translation of Title Management of Anaphylaxis in Emergency Department.
Authors Sarkio, Joel Sakari
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Pages 24
Keywords [eng] Management,Anaphylaxis, Emergency department, Pathophysiology, Diagnosis, Adrenaline, corticosteroids, antihistamines
Abstract [eng] Anaphylaxis is frequent problem at the emergency department. There are currently very heterogenic practices and guidelines about anaphylaxis starting already from the different definitions. This thesis dives deeper into pathophysiology of anaphylaxis and then to the evidence behind the different guidelines and practices and tries to establish that which practices are on solid base and which not. This thesis was done as narrative literature review using mostly recent studies published in reputable journals. During the search of literature, it was found that there were very variable criteria used for diagnosing and managing anaphylaxis and currently there is no consensus which criteria are best, reflecting the heterogeneous practices and management in different parts of world. It seems that anaphylaxis is severely underdiagnosed and often as well misdiagnosed. In the thesis it was established that there is evidence that for some reason physicians are reluctant to administer adrenaline and thus some parts of the world are moving to less strict indications for administrating adrenaline. The usage of corticosteroids and antihistamine instead of adrenaline to anaphylaxis have remained extremely high, especially in USA. However, there is increasingly more new evidence that corticosteroids and antihistamine administration to anaphylaxis will cause mismanagement, misdiagnosis and even potentially can be harmful. Some countries have drawn their conclusions like UK, Australia and New Zealand and are not recommending antihistamines or corticosteroids at all anymore.
Dissertation Institution Vilniaus universitetas.
Type Master thesis
Language English
Publication date 2023